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| Meta-analysis of the therapeutic effect and safety of silymarin in the treatment of nonalcoholic fatty liver disease |
| HUANG Qian1, WU Yin-lian2, KANG Na-ling2 |
1.Department of Infectious,the Xiehe Affiliated Hospital of Fujian Medical University in Fujian Province,Fuzhou 350000,China;
2.Department of Liver Center, the First Affiliated Hospital of Fujian Medical University in Fujian Province,Fuzhou 350000,China |
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Abstract Objective To evaluate the therapeutic effect and safety of silymarin in the treatment of nonalcoholic fatty liver disease (NAFLD).Methods RCT articles about treating NAFLD with silymarin were published in databases including PubMed,Embase,the Cochrane Library,CBM,Wanfang Data,VIP,and CNKI before July 2016 were searched.The included articles were used to extract data and assess the methodology quality according the inclusion/exclusion criteria.Then all the datas were analyzed with RevMan 5.3.Results A total of 14 artilces including 1337 cases were fitted for Meta-analysis.After treatment,ALT,AST,TG and BMI were significant different between silymarin-treated group and control group (ALT:WMD=-14.16,95%CI (-22.02,-6.30),P=0.0004;AST:WMD=-9.17,95%CI (-14.20,-4.15),P=0.0003;TG:WMD=-0.23,95%CI (-0.42,-0.03),P=0.02;BMI:WMD=-0.84,95%CI (-1.34,-0.34),P=0.001.The subgroup analysis showed ALT and AST were significantly different between silymarin-treated group and control group in NAFLD cases,but not in NASH cases.The adverse reactions were low and mild.Conclusion Silymarin can improve ALT,AST,TG and BMI with low adverse reactions according limited evidence for now.
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Received: 20 June 2017
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