早期联合应用氯吡格雷与丁苯酞软胶囊治疗脑梗死临床效果

Abstract
Figure/Table
References (15)
Related Citation (15)

Download: PDF (0 KB) HTML (31 KB)
Export: BibTeX | EndNote (RIS)

Abstract ObjectiveTo analyze the clinical efficacy of early combined application of Clopidogrel and Butylphthalide Soft Capsule in the treatment of cerebral infarction.MethodsA total of 90 patients with cerebral infarction who were admitted to our hospital from May 2016 to May 2017 were randomly selected as the subjects of this study.The patients were divided into the control group and the observation group according to the method of random number table,with 45 patients in each group.The control group was given routine treatment after inclusion and confirmed diagnosis,including neuroprotection,dehydration for the reduction of intracranial pressure,elimination of free radicals,statin for lipid adjustment,etc,and Clopidogrel was used for combined application.The patients in the observation group were given early application of Clopidogrel combined with Butylphthalide Soft Capsules on the basis of the control group.The follow-up visit was for a one month.The differences of the clinical efficacy,neurological function and daily living ability were compared between the two groups.ResultsThe total effective rate was 93.33% (42/45)in the observation group,which was significantly higher than that in the control group 68.89%(31/45),and there was significant difference between the two groups,which was statistically significant(P<0.05).There was no significant difference in NIHSS score and ADL score between the two groups before treatment,and it was not statistically significant(P>0.05);the NIHSS score was[(6.3±1.2)points]in the observation group in the last follow-up visit,which was significantly lower than that in the control group.ADL score was[(68.3±5.2)points],which was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).ConclusionThe clinical efficacy of the early combined application of Clopidogrel and Butylphthalide Soft Capsules in the treatment of cerebral infarction is exact,and plays a positive role in improving the degree of neurological deficits in patients,and improving the ability of daily activities,which is worthy of promotion in clinical practice.

Key words： Cerebral infarction Clopidogrel Butylphthalide Soft Capsules

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	LI Yuan

Cite this article:

LI Yuan. Clinical efficacy of early combined application of Clopidogrel and Butyphthalide Soft Capsules in the treatment of cerebral infarction[J]. 中国当代医药, 2017, 24(33): 91-93.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I33/91

[1]	彭慕立，苏赤，肖彧，等.阿司匹林联合氯吡格雷治疗大脑中动脉狭窄脑梗死的临床研究[J].中国当代医药，2014，21（9）：80-82.
[2]	章莹.阿托伐他汀钙对脑梗死患者颈动脉斑块、血脂及神经功能的影响[J].中国当代医药，2012，19（10）：86-87.
[3]	李瑞宝.氯吡格雷联合氟伐他汀治疗脑梗死的临床效果观察[J].中国当代医药，2015，22（4）：85-87.
[4]	方莉伟，郭浩杰.阿司匹林联合氯吡格雷治疗脑梗死的效果分析[J].中国当代医药，2014，21（9）：76-77，82.
[5]	吴娟，陈永.丁苯酞对急性脑梗死患者临床疗效及血液流变学的影响[J].重庆医学，2012，41（33）：3488-3489.
[6]	王新，王默力，杨盛，等.丁苯酞软胶囊（恩必普）联用尤瑞克林注射液治疗大面积脑梗死的临床疗效研究[J].中国医科大学学报，2014，43（12）：1136-1138.
[7]	刘昌云，陈技挺，黄华品，等.丁苯酞注射液对急性脑梗死患者血清NO和NOS表达及临床疗效的影响[J].中国老年学杂志，2013，33（14）：3448-3449.
[8]	靳玫，马世江，沈长波，等.丁苯酞对脑梗死认知障碍患者记忆运动及事件相关电位的影响[J].重庆医学，2017，46（14）：1907-1909.
[9]	孔起良，刘娟，杨震，等.早期使用丁苯酞注射液治疗基底节区脑梗死对侧支循环建立及神经功能的影响[J].临床神经病学杂志，2016，29（4）：293-295.
[10]	程冉冉，李焰，周燕，等.丁苯酞联合依达拉奉对急性脑梗死患者血清SOD、MDA的影响[J].中国老年学杂志，2014，（11）：2974-2975.
[11]	陈进玲，唐树芝.丁苯酞联合山楂叶总黄酮治疗老年脑梗死的疗效及对外周血神经元特异性烯醇化酶的影响[J].实用医学杂志，2016，32（7）：1064-1067.
[12]	章凯，胡北平.左西孟旦联合丁苯酞对脑梗死患者血清MMP-9及血流动力学影响[J].中国生化药物杂志，2016，（10）：54-57.
[13]	王国军，马涛.氟伐他汀与丁苯酞软胶囊联合治疗急性脑梗死的疗效及对血清C反应蛋白的动态影响[J].中国生化药物杂志，2014，35（7）：150-152.
[14]	白丽虹，张燕如.丁苯酞注射液联合低分子肝素钙治疗进展性脑梗死的临床效果[J].中国老年学杂志，2016，36（10）：2394-2396.
[15]	尹春丽，王耀伍，吕佩源，等.丁苯酞联合尤瑞克林对急性脑梗死患者缺血低灌注区面积的影响及临床疗效评价[J].中国中西医结合急救杂志，2016，23（6）：565-567.