血清胱抑素C在早期糖尿病患者肾小球损害诊断中的应用价值

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Abstract Objective To explore the application value of cystatin C (CysC)in in diagnosis of glomerular damage in patients with early diabetic mellitus (DM).Methods All of 196 patients with DM treated in our hospital from March 2016 to March 2018 were retrospectively analyzed,and the patients with diabetic nephropathy(DN)were set as the observation group (102 cases)while patients with simple DM were set as the control group (94 cases).CysC,BUN and SCr level inpatients between the two groups were compared,and ROC curve was used to evaluate the diagnostic value of the above-mentioned indexes for DN.Results The level of CysC,BUN and SCr in the observation group were significantly higher than those in the control group,and the differences were statistically significant(P＜0.05).ROC curve analysis showed that the diagnostic efficacy of serum CysC for DN was significantly higher than that of BUN and SCr(P＜0.05),the AUC was 0.885,0.715,0.748 respectively.The Youden index indicated that the best cut-off points of CysC,BUN and SCr expression level for diagnosis of DN was≥0.797 mg/L,≥7.273 mmol/L and ≥127.741 μmol/L respectively.The accuracy,sensitivity,specificity,positive predictive value and negative predictive value of CysC were significantly higher than those of BUN and sCR,and the differences were statistically significant(P＜0.05).Conclusion CysC has higher sensitivity and specificity in the diagnosis of glomerular damage in patients with early DM.It is worthy of clinical promotion.

Key words： Diabetic nephropathy Cystatin C Early diagnosis Blood urea nitrogen Serum creatinine

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