冻干重组人脑利钠肽联合左西孟旦治疗急性心力衰竭的临床效果

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Abstract Objective To study the clinical effect of Lyophilized Recombinant Human Brain Natriuretic Peptide combined with Levosimendan in patients with acute heart failure.Methods Ninety-two patients with acute heart failure admitted to the First People's Hospital of Hechi City from April 2017 to April 2018 were selected as the data subjects.According to the random number table method,they were divided into study group(n=46)and control group(n=46).Patients in the control group were treated with Levosimendan alone,while those in the study group were treated with Lyophilized Recombinant Human Brain Natriuretic Peptide combined with Levosimendan.The clinical treatment efficiency of the two groups was compared.The changes of B-type natriuretic peptide level,serum uric acid level and cardiac function indexes (left ventricular ejection fraction [LVEF]and left ventricular end-diastolic diameter[LVEDD])before and after treatment in the two groups were compared.Results The total effective rate in the study group was higher than that in the control group,and the difference was statistically significant(P＜0.05).Before treatment,there were no statistically significant differences in B-type natriuretic peptide level,serum uric acid level,LVEF and LVEDD between the two groups(P＞0.05).After treatment,the level of B-type natriuretic peptide and serum uric acid in the study group were significantly lower than those in the control group,and LVEF and LVEDD were significantly higher than those in the control group,with statistically significant differences(P＜0.05).After treatment,the level of B-type natriuretic peptide and serum uric acid in the two groups were significantly lower than those before treatment,and LVEF and LVEDD were significantly higher than those before treatment,with statistically significant differences (P＜0.05).Conclusion The application of Lyophilized Recombinant Human Brain Natriuretic Peptide combined with Levosimendan in the treatment of acute heart failure is beneficial to the improvement of clinical treatment.

Key words： Acuteheartfailure Levosimendan Lyophilized Recombinant Human Brain Natriuretic Peptide Effect of combination therapy

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	YANG Li-hui

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YANG Li-hui. Clinical effect of Lyophilized Recombinant Human Brain Natriuretic Peptide combined with Levosimendan in the treatment of acute heart failure[J]. 中国当代医药, 2019, 26(3): 120-122.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2019/V26/I3/120

[1]	曹俊雄，朱志军，吴丹宁.冻干重组人脑利钠肽联合左西孟旦治疗急性心力衰竭的临床观察[J].中国药房，2016，27（8）：1091-1093.
[2]	杨贤义，刘梅，柴林，等.冻干重组人脑利钠肽联合左西孟旦对急性心力衰竭的疗效及对UA和BNP的影响[J].中国临床研究，2017，30（6）：767-769.
[3]	王文龙.左西孟旦与重组人脑利钠肽联合应用治疗急性心衰的疗效观察[J].河北医学，2016，22（9）：1535-1536.
[4]	颜培实.左西孟旦、重组人脑利钠肽对老年失代偿性心力衰竭的治疗效果及血流动力学的影响[J].中国心血管病研究，2017，15（9）：845-848.
[5]	诸小飞，陆躖.左西孟旦治疗缺血性心肌病并顽固性心力衰竭疗效观察[J].心脑血管病防治，2017，17（6）：446-447.
[6]	杨平，李垚，陈万林.左西孟旦联合重组人脑利钠肽治疗急性失代偿性心力衰竭患者的疗效[J].中国循证心血管医学杂志，2016，8（8）：958-960.
[7]	吴淑彬，丁力平，靳志涛，等.左西孟旦与重组人脑利钠肽治疗急性失代偿性心力衰竭效果对比研究[J].天津医药，2016，44（6）：789-792.
[8]	张春晓，陈玉东.左西孟旦与重组人脑利钠肽治疗AMI急诊PCI术后患者短期临床疗效的对比[J].临床心血管病杂志，2017，23（1）：39-43.
[9]	黄卫.参附注射液联合左西孟旦治疗急性心力衰竭的临床疗效及其对患者炎性细胞因子和血管内皮细胞功能的影响[J].实用心脑肺血管病杂志，2016，24（12）：244-247.
[10]	杨茂勇，李俊霞，张保金，等.重组人钠脲肽联合左西孟旦对急性失代偿心力衰竭患者LVEF和BNP水平的影响[J].临床药物治疗杂志，2016，14（6）：64-67.
[11]	鲁锋，马树人，刘涛，等.左西孟旦治疗急性冠脉综合征合并急性心力衰竭34例临床研究[J].中国临床研究，2017，30（7）：942-944.
[12]	王磊.左西孟旦、米力农与多巴酚丁胺治疗急性失代偿心力衰竭患者临床疗效及安全性评价[J].药物评价研究，2017，40（1）：92-95.
[13]	高波.左西孟旦在慢性心衰急性发作中的临床疗效观察[J].医学临床研究，2016，33（9）：1744-1746.
[14]	白延涛.左西孟旦治疗心力衰竭的临床疗效观察[J].实用心脑肺血管病杂志，2016，24（2）：57-59.
[15]	宁雕，陈素芹.二丁酰环磷腺苷联合左西孟旦治疗慢性心力衰竭的临床研究[J].现代药物与临床，2018，33（5）：1056-1059.