一贯煎加减联合甲氨蝶呤、羟氯喹治疗干燥综合征的临床效果

Abstract
Figure/Table
References (15)
Related Citation (15)

Download: PDF (0 KB) HTML (35 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the clinical effect of Yiguan Decoction Add or Reduce Medicine combined with Methotrexate and Hydroxychloroquine in the treatment of Sjogren syndrome.Methods From January 2016 to December 2017,60 patients with Sjogren syndrome admitted to the First People′s Hospital of Jiujiang City in Jiangxi Province were selected as subjects.Patients were divided into control group(30 cases)and treatment group(30 cases)according to random number table method.The control group was treated with Methotrexate combined with Hydroxychloroquine.The treatment group was treated with Yiguan Decoction Add or Reduce Medicine combined with Methotrexate and Hydroxychloroquine.The total effective rate was compared between the two groups after 8 weeks of treatment.The results of eye Schimer test,dry mouth symptom score,dry eyes symptom score,serum C-reactive protein (CRP)level and erythrocyte sedimentation rate (ESR)at 4 and 8 weeks of treatment were compared between the two groups.Results The total effective rate of treatment in the treatment group was higher than that in the control group,and the difference was statistically significant (P＜0.05).The results of the Schimer test at 8 weeks of treatment were significantly higher than that at 4 weeks of treatment,the differences were statistically significant(P＜0.05).The results of the Schimer test in the treatment group at 4 and 8 weeks of treatment were significantly higher than those in the control group,the differences were statistically significant(P＜0.05).The scores of dry eyes and dry mouth at 8 weeks of treatment were significantly lower than those at 4 weeks of treatment,the differences were statistically significant(P＜0.05).The scores of dry eyes and dry mouth in the treatment group at 4 and 8 weeks of treatment were significantly lower than those in the control group,the differences were statistically significant(P＜0.05).The CRP and ESR levels at 8 weeks of treatment in both groups were significantly lower than that at 4 weeks of treatment,the differences were statistically significant(P＜0.05).The CRP and ESR levels in the treatment group at 4 and 8 weeks of treatment were significantly lower than those in the control group,with statistically significant differences (P＜0.05).Conclusion Yiguan Decoction Add or Reduce Medicine combined with Methotrexate and Hydroxychloroquine in the treatment of Sjogren syndrome,the clinical efficacy is better than Methotrexate combined with Hydroxychloroquine treatment.

Key words： Sjogren syndrome Yiguan DecoctionAdd or Reduce Medicine Methotrexate Hydroxychloroquine Combination therapy

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors

Cite this article:

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2019/V26/I3/99

[1]	张帅，杜羽，包洁，等.范永升应用一贯煎治疗干燥综合征验案举隅[J].浙江中医药大学学报，2016，40（12）：917-919.
[2]	姜淑华，胡丽伟，平利峰，等.一贯煎联合谷胱甘肽治疗干燥综合征肝损伤的临床观察[J].陕西中医，2016，37（9）：1217-1218.
[3]	姚专.一贯煎加味治疗原发性干燥综合征32例临床观察[J].江西中医药，2017，48（11）：46-48.
[4]	华红.干燥综合征西医、中医治疗研究进展[J].中国实用口腔科杂志，2012，5（3）：142-145.
[5]	李尚坤，邬松涛，吴海娟.羟氯喹治疗原发性干燥综合征的效果研究[J].中国现代医生，2013，51（20）：59-60.
[6]	韩龙，孙桂芳.滋阴润燥生津汤联合硫酸羟化氯喹治疗干燥综合征临床研究[J]中医药信息，2014，5（3）：60-63.
[7]	彭敏锋.羟氯喹联合胸腺肽治疗干燥综合征疗效分析[J].当代医学，2015，21（32）：146-147.
[8]	尹晓娜.中西医结合治疗口腔干燥综合征的临床效果探讨[J].中国处方药，2016，14（5）：79-80.
[9]	田怀平，周佳，单剑萍，等.羟氯喹用于干燥综合征治疗的调研与系统评价[J].世界临床药物，2017，38（6）：403-407.[10]罗敏.中西医结合治疗干燥综合征临床观察[J].实用中医药杂志，2018，34（2）：190-191.
[11]	孙晓泽，焦东方，刘爱华.中西医结合治疗干燥综合征思路探讨[J].中华中医药杂志，2018，33（7）：2956-2959.
[12]	刘怡，邓昊.帕夫林胶囊联合甲氨蝶呤治疗干燥综合征的临床分析[J].中华全科医学，2016，14（2）：230-231.
[13]	陈鑫，周绍鹏.中西医综合疗法治疗原发性干燥综合征干眼的临床效果[J].中西医结合心血管病电子杂志，2018，6（9）：169.
[14]	胡丽霞.一贯煎治疗原发性干燥综合征疗效观察与护理体会[J].中医临床研究，2018，10（1）：136-137.
[15]	李晋宏.一贯煎加减治疗灼口综合征验案1则[J].内蒙古中医药，2016，35（4）：54.