|
|
|
| Application of thinprep cytologic test combined with HPV-DNA detection in diagnosis of cervical lesions |
| ZHUANG Jian SHI Feng-quan LI Wen-zhong YUAN Yuan-ying FENG Xu-fen LI Li-li |
| Department of Clinical Laboratory,Ganzhou Maternal and Child Health Hospital,Jiangxi Province,Ganzhou 341000,China |
|
|
|
|
Abstract Objective To investigate the application effect of thinprep cytologic test (TCT) combined with HPV-DNA detection in the diagnosis of cervical lesions.MethodsSixty-six patients with suspected cervical lesions enrolled in the Department of Obstetrics and Gynecology of our hospital from June 2017 to May 2018 were selected as the subjects.The TCT test and HPV-DNA test were performed respectively.The results of cervical biopsy were used as the gold standard.The sensitivity,specificity,and accuracy of TCT alone,HPV-DNA alone,and joint detections in cervical lesions were analyzed.Results The accuracy,sensitivity and specificity of detections in combination were 95.45%,95.83%,and 94.44%,higher than those of TCT alone accuracy,sensitivity and specificity (63.64%,68.75%,and 50.00%)and HPV-DNA alone (68.18%,72.92%,and 55.56%) in turn,with significant differences (P<0.05).There was no significant difference in sensitivity,specificity or sensitivity of TCT alone and HPV-DNA alone (P>0.05).Conclusion In the diagnosis of patients with early cervical lesions,the combined use of TCT and HPV-DNA tests is beneficial to the early diagnosis of its nature.The diagnostic accuracy is high,and can provide a reliable reference for clinical treatment.It is worth further in clinical practice.
|
|
|
|
|
|
| [1] |
吴敏，王华，龚颖萍，等.使用同一新柏氏保存液进行TCT检查和Cervista 高危型HPV 检测的临床研究[J].中国医师杂志，2016，18（1）：42-46.
|
| [2] |
车洪智，马飞，付玉荣，等.探讨模式液基薄层细胞学检测（TCT）技术和高危型HPV-DNA 检测与宫颈病变的相关性[J].中国医学装备，2017，14（3）：76-79.
|
| [3] |
齐艳红.宫颈病变筛查中宫颈液基薄层细胞学检查与HPVDNA 检测的联合应用观察[J].山东医药，2016，56（19）：58-59.
|
| [4] |
迟少珍.新柏氏液基薄层细胞学检测联合CervistaHPVHR技术在宫颈癌筛查中的应用价值[J].临床和实验医学杂志，2016，13（13）：1312-1314.
|
| [5] |
刘晓芸，彭胡丹.人乳头瘤病毒DNA 联合液基薄层细胞学检查在宫颈病变诊断中的应用[J].实用临床医药杂志，2016，20（3）：91-94.
|
| [6] |
林志金，曾宪瑞，王明波，等.宫颈液基细胞学检查联合HPV-DNA 检测在宫颈癌筛查中的应用[J].江西医药，2016，51（5）：477-478.
|
| [7] |
左学骞，舒丽莎，吕亚淑，等.TCT 联合CervistaHPVHR 在宫颈癌筛查中的应用价值[J].中国妇幼保健，2015，30（3）：457-459.
|
| [8] |
吴涛，张俊华，何瑞芬，等.hrHPV 检测、亚型分析与TCT筛查结果联合在宫颈癌筛查中的应用研究[J].宁夏医学杂志，2017，39（8）：722-724.
|
| [9] |
张燕，杨红梅，董丽萍，等.宫颈脱落细胞学病理组织学检查和人乳头瘤样病毒检测在诊断宫颈病变中的临床意义[J].河北医学，2014，20（9）：1509-1511.
|
| [10] |
胡利丹，卢雪映，胡月南，等.宫颈病变患者HPV 感染的流行病学调查及危险因素分析[J].中华医院感染学杂志，2017，27（22）：5212-5215.
|
| [11] |
李开颜，蔡海莹，沈慧敏.FRD 上皮组织特殊染色液筛查宫颈病变的应用研究[J].基因组学与应用生物学，2016，35（7）：1584-1588.
|
| [12] |
方晏红.新柏氏液基细胞学技术高危型人乳头状瘤病毒检测及阴道镜检查对宫颈病变的诊断意义分析[J].黑龙江医学，2016，40（5）：438-440.
|
| [13] |
蒙志平，黎勇明，杨玲，等.宫颈细胞HPVE6/E7mRNA 检测在宫颈病变诊断中的价值研究[J].国际检验医学杂志，2016，37（21）：2987-2989.
|
| [14] |
潘琪，杨二姣，韩大芬，等.TCT 联合HPV 检测诊断宫颈病变的临床价值分析[J].现代生物医学进展，2015，15（1）：80-83.
|
| [15] |
唐恒锋，卢红琼，唐文.P16 蛋白和TCT 及HPV 基因分型联合检测在宫颈病变筛查中的应用[J].浙江预防医学，2014，26（12）：1271-1273.
|
|
|
|
