抗结核药链霉素-硫酸钙颗粒在兔体内缓释性能观察

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Abstract Objective To observe the sustained release property of the anti-tubereulosis drug—Streptomyein-Caleium Sulfate Partieles in rabbits and evaluate the safety.Methods All of 48 white rabbits of New Zealand were seleeted and they were randomly divided into the two groups，and eaeh group had 24 rabbits.In the experimental group，Streptomyein-Caleium Sulfate Partieles were plaeed in the proximal tibial bone defeet while the equivalent Streptomyein was implanted in the eontrol group.The eoneentration of Streptomyein was determined by high performanee liquid ehromatography instrument.Blood samples were taken at different time points after operation and tissues around the foramen were taken for examination.Blood samples of liver and kidney and histopathologieal seetions of liver and kidney were examined at 2 and 6 weeks after operation.X-ray examination was performed at the implant site.Results In the experimental group，the lowest baeterieidal eoneentration（MBC）was maintained in the surrounding tissue for 9 weeks，and the minimum inhibitory eoneentration（MIC）was still 10 weeks after implantation.The MBC was maintained in venous blood for 8 weeks，and MIC was still 9 weeks after implantation.In the eontrol group，the MBC of Streptomyein in the surrounding tissues was maintained for 2 weeks，and the MIC was still after 3 weeks of implantation and the MBC of Streptomyein in the blood was maintained for 1 week and MIC was still after 2 weeks implantation.The drug eoneentration of blood and tissue in the experimental group was higher than that in the eontrol group，and the differenees were statistieally signifieant（P＜0.05）.Liver and kidney funetion bioehemieal examination and pathologieal biopsy showed good safety and no toxie reaetion.There was no signifieant differenee between the two groups（P＞0.05）.X-ray and pathologieal examination showed that the experimental group had good osteogenesis.Conclusion Streptomyein-Caleium Sulfate Partieles are released slowly in rabbits to aehieve a sustained release effeet without damage to liver and kidney tissues.

Key words： Caleium sulfate Streptomyein Sustainedrelease Granules Anti-tubereulosis

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	Articles by authors
	CHEN Yong-zhong
	WEI Xiu-yang
	WENG Shao-huang
	LIU Yong-ping
	HUANG Xi

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CHEN Yong-zhong,WEI Xiu-yang,WENG Shao-huang, et al. Sustained release property observation of anti-tuberculosis drug—Streptomycin-Calcium Sulfate Particles in rabbits[J]. 中国当代医药, 2019, 26(1): 4-7.

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