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| Application effect of Statin intensive treatment regimen in the patients with acute cerebral infarction |
| HUANG Wei-dong LI Liang LIANG Shi-pan ZHAO Qin-lian |
| Department of Neurology,People′s Hospital in Xinhui District,Guangdong Province,Jiangmen 529100,China |
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Abstract Objective To investigate the application effect of Statin intensive treatment regimen in the patients with acute cerebral infarction.Methods A total of 120 patients with acute cerebral infarction who were treated in the department of neurology in our hospital from January 2016 to February 2018 were selected as subjects and were divided into two groups according to the number grouping method.All patients were given conventional medication.On this basis,the control group was given Atorvastatin Calcium of 20 mg/d for treatment.The observation group was given Atorvastatin Calcium of 40 mg/d for treatment.The clinical efficacy,changes in neurological function before and after treatment,changes in blood lipids and C-reactive protein (CRP)levels,and safety were compared between the two groups.Results The total effective rate in the observation group was 91.67%,which was significantly higher than that of 76.67%in the control group,the difference was statistically significant(P<0.05).The National Institutes of Health Stroke Scale(NIHSS)and the modified Rankin Scale score after treatment in the observation group were significantly lower than in the control group,the differences were statistically significant(P<0.05).Activities of daily living(ADL)score in the observation group was significantly higher than that in the control group,and the differences were statistically significant(P<0.05).The total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C)and CRP in the observation group after treatment were significantly lower than those in the control group,high-density lipoprotein cholesterol(HDL-C)in the observation group was significantly higher than those in the control group,the differences were statistically significant(P<0.05).There were no significant differences in incidence of adverse drug reactions,such as digestive discomfort,insomnia,and transient calf muscle pain,which in the observation group compared with the control group (P>0.05).Conclusion The statin intensive treatment regimen has a significant effect in patients with acute cerebral infarction,which can reduce the mortality rate and disability rate and improve the quality of life.At the same time,it does not significantly increase the adverse reactions of statins,and has a positive clinical significance.
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