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| Effect Contrast of Levosimendan and Dobutamine Hydrochloride on acute heart failure and its effect on the level of BNP |
| TAN Wei-hua QING Guo-zhong LU Wei PENG Zheng-liang |
| Department of Emergency,the First Affiliated Hospital of Nanhua University,Hu′nan Province,Hengyang 421001,China |
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Abstract Objective To discuss the effect of Levosimendan and Dobutamine Hydrochloride on the treatment of acute heart failure and its effect on the level of BNP.Methods A total of 100 patients with acute heart failure who were admitted to our hospital from February 2017 to March 2018 were selected as study objects and divided into two groups according to the random number table method.And 50 patients in the control group were treated with Dobutamine Hydrochloride,and 50 patients in the observation group were treated with Leosimendan.Routine examination and standard medication were administered to both groups.After 7 days of treatment,the clinical effects of the two groups were compared.The improvement of the left ventricular end-systolic volume (LVESV),left ventricular end-diastolic volume(LVEDV),left ventricular ejection fraction (LVEF)and stroke volume (SV)of the two groups were compared.The changes of brain natriuretic peptide(BNP),inflammatory molecular indicators[interleukin-6(IL-6),tumor necrosis factor-α (TNF-α),hypersensitive c-reactive protein(hs-CRP)]in the two groups were compared.Adverse reactions were compared between the two groups.Results After the treatment,the overall effective rate of clinical treatment in the observation group was higher than that in the control group,the difference was statistically significant(P<0.05).After treatment,the LVESV and LVEDV in the two groups were lower than those before treatment,the LVEF was higher than that before treatment,and SV in the observation group was higher than that before treatment,the differences were statistically significant(P<0.05).After treatment,the LVESV in the observation group was lower than the control group,and LVEF and SV were higher than those in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of BNP,IL-6,TNF-α,and hs-CRP in the two groups were all lower than those before treatment,the differences were statistically significant(P<0.05).And the levels of BNP,IL-6,TNF-α,and hs-CRP in the observation group were all lower than those in the control group,the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The clinical effect of Leosimendan on the treatment of acute heart failure is better than that of Dobutamine Hydrochloride.And Leosimendan can reduce the level of BNP and be reliability.
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