高敏C反应蛋白、脑钠肽变化与心力衰竭患者心功能的关系

Abstract
Figure/Table
References (18)
Related Citation (15)

Download: PDF (0 KB) HTML (42 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To compare and analyze the results of high sensitivity C-reactive protein and brain natriuretic peptide in the treatment of patients with heart failure,and to study its relationship with heart function.Methods A total of 90 patients with chronic heart failure from January 2014 to January 2017 in our hospital were selected as the heart failure group,and their cardiac function was classified according to NYHA standards in international standards.The group name was secondary group,tertiary group,and quaternary group.There were 30 patients in each group.Another 30 healthy people were selected during the same period as the study group,and they were assigned to the regular group after their vital signs were determined to be normal.The levels of brain natriuretic peptide,high-sensitivity C-reactive protein,left ventricular ejection fraction,and the level of internal diameter at the end of diastolic degree were compared between the two groups.The changes of each indicator before and after the treatment were compared in the patients.The above data were compared with the data 6 months after receiving the treatment,and the changes were observed.In addition,the occurrence of cardiovascular and cerebrovascular events in the patients was understood through follow-up visits.The four indicators of BNP,hs-CRP,LVEF,and LVDD in the patients who had an incident and those who did not have an incident were compared.Results Before treatment,hs-CRP([12±2]mg/L),BNP([483±16]ng/L),and LVDD([58±2]mm)in the heart failure group were higher than those in the conventional group([3±1]mg/L,[33±13]ng/L,[42±2]mm),and LVEF([31±3]%)was lower than those inthe conventional group([43±4]%).The differences were statistically significant(P<0.05).Patients in the heart failure group had higher levels of hs-CRP([10±1]mg/L),BNP([129±21]ng/L),and LVDD([46±2]mm)than those in the conventional group after treatment,and LVEF([43±4]%)was lower than that in the conventional group.However,the levels of hs-CRP([10±1]mg/L),BNP([129±21]ng/L),and LVDD([46±2]mm)after treatment in the heart failure group were lower than those before treatment,and LVEF ([43±4]%)was higher than that before treatment.The differences were statistically significant(P<0.05).Patients in the tertiary group had BNP of(427±41)ng/L,LVDD of(58±3)mm,and hs-CRP of(12±3)mg/L.In the quaternary group,BNP was(780±59)ng/L,LVDD was (64±3)mm,and hs-CRP was (780±59)mg/L.The above indicators in the tertiary group and quaternary group were higher than those in the secondary group.The above indicators in the quaternary group were higher than those in the tertiary group.The differences were statistically significant(P<0.05).Six months after discharge,20 cases of the patient experienced secondary deterioration,and 70 cases did not appear any events.The levels of BNP,hs-CRP and LVDD in the patients with cardiovascular deterioration were higher than those in patients without cardiovascular deterioration.However,the left ventricular function was lower than the group without heart failure,and LVEF was lower than the group without heart failure.The differences were statistically significant(P<0.05).Patients in the tertiary group had BNP of(427±41)ng/L,LVDD of(58±3)mm,and hs-CRP of(12±3)mg/L.In the quaternary group,BNP was(780±59)ng/L,LVDD was(64±3)mm,and hs-CRP was(780±59)mg/L.The above indicators in the tertiary group and quaternary group were higher than those in the secondary group.The above indicators in the quaternary group were higher than those in the tertiary group.The differences were statistically significant(P<0.05).Six months after discharge,20 cases of the patient experienced secondary deterioration,and 70 cases did not appear any events.The levels of BNP,hs-CRP and LVDD in the patients with cardiovascular deterioration were higher than those in patients without cardiovascular deterioration.However,the left ventricular function was lower than the group without heart failure,and LVEF was lower than the group without heart failure.The differences were statistically significant(P<0.05).Conclusion The changes of high-sensitivity C-reactive protein and brain natriuretic peptide in heart failure can be used as a reliable indicator for the diagnosis of chronic heart failure.It also can provide an effective reference for checking the effective classification of disease levels after diagnosis.

Key words： Heart failure High sensitivity C-reactive protein Brain natriuretic peptide Heart function

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors

Cite this article:

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I22/66

[1]	王晓垒，赵国安.慢性心力衰竭患者血浆脑钠肽、尿酸及高敏C反应蛋白水平与心肾功能的相关性[J].新乡医学院学报，2017，34（8）：762-765.
[2]	王浩宇，衣欣，胡奉环.高敏C反应蛋白和血浆N末端原脑钠肽对老年心力衰竭患者预后的影响[J].临床和实验医学杂志，2017，16（1）：63-65.
[3]	张彦莉，王瑞英，薛红梅.慢性心力衰竭患者高敏C反应蛋白和CA125与心功能的关系[J].中西医结合心脑血管病杂志，2013，11（3）：306-307.
[4]	陈简庆，张民乐，吴伟军.冠心病心力衰竭患者血尿酸、脑钠肽、高敏C反应蛋白与左室射血分数的相关性分析[J].实用医学杂志，2012，28（2）：239-240.
[5]	徐元杰，陈小燕，孔繁亮，等.心电监测指标对急性心衰住院患者预后价值的评估[J].江苏实用心电学杂志，2016，25（1）：24-27.
[6]	王洪静，周雪艳.心力衰竭患者血清脂蛋白相关磷脂酶A2和B型尿钠肽的表达[J].中国老年学杂志，2017，37（4）：847-848
[7]	王晓艳，应光荣，骆金伟，等.N端脑钠肽前体、高敏C反应蛋白、左心室射血分数与不同类型冠心病及冠脉病变程度相关性分析[J].医学研究杂志，2016，45（4）：126-129.
[8]	中华医学会心血管病学分会，中华心血管病杂志编辑委员会.中国心力衰竭诊断和治疗指南2014[J].中华心血管病杂志，2014，42（2）：98-122
[9]	蒋敏勇，祝兴超，高永兴，等.心脏瓣膜病合并心力衰竭患者血浆 BNP、cTnI、UA水平变化及意义[J].山东医药，2016，56（46）：71-73.
[10]	金卫东，刘艳宾，陈娟.心力衰竭患者肺部感染脑钠肽、肿瘤坏死因子-α及白细胞介素-6变化与心功能的关系[J].中华医院感染学杂志，2013，23（16）：3835-3837.
[11]	王梅香，殷屹岗，陈各才.血浆抵抗素水平与心房颤动关系的临床研究[J].江苏实用心电学杂志，2016，25（5）：359-362.
[12]	李俊梅，王雪梅.急性心力衰竭患者血清激活素A和B型钠尿肽水平变化及意义[J].山东医药，2017，57（6）：68-69.
[13]	马宁，晁银霞，杨红，等.血浆脑钠肽及血清胱抑素C对ARVC心力衰竭的预测价值研究[J].重庆医学，2017，46（27）：3819-3821，3824
[14]	邢阿光，黄贤胜，夏爽，等.不同病因心力衰竭患者血清脑钠肽水平观察[J].山东医药，2016，56（27）：70-72.
[15]	王国余，许岑.无创呼吸机双向正压通气救治急性左心衰临床疗效[J].实用心电学杂志，2017，26（5）：328-330.
[16]	郭丽，张丽，曲红玉.心脉隆注射液对慢性心力衰竭病人心功能和炎性因子水平的影响[J].中西医结合心脑血管病杂志，2016，14（15）：1762-1764.
[17]	沈胜强，赵萌秋，张开坤，等.黄芪注射液联合β受体阻滞剂对老年心力衰竭患者 BNP、IL－1β、IL－6 及 TNF－α 的影响[J].中国生化药物杂志，2016，36（4）：150-151，154.
[18]	郭玉君，杨峰，孙娟，等.慢性心力衰竭老年患者不同心功能分级与相关血清学指标的关系研究[J].新疆医科大学学报，2016，39（7）：862-865.