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| Influence of Buchang Naoxintong on microinflammation markers and carotid intima-media thickness |
| LIANG Li-yan1 LIAO Jian-jun2 CHENG Yan-li3 |
1.Department of Nephrology,Beishan Hospital of Lianzhou City,Guangdong Province,Lianzhou 513400,China;
2.Department of Imaging,Beishan Hospital of Lianzhou City,Guangdong Province,Lianzhou 513400,China;
3.Hemodialysis Room,Beishan Hospital of Lianzhou City,Guangdong Province,Lianzhou 513400,China |
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Abstract Objective To investigate the effect of Buchang Naoxintong on microinflammation markers and carotid intima-media thickness.Methods The clinical data of 60 patients with maintenance hemodialysis(MHD)admitted to our hospital from August to December 2017 were analyzed.According to whether or not the patients were treated with Buchang Naoxintong,they were equally divided into control group (basic treatment)and observation group(Buchang Naoxintong treatment),30 cases in each group.The levels of interleukin-6(IL-6),C-reactive protein(CRP)and tumor necrosis factor-α (TNF-α),carotid intima-media thickness(IMT),maximum thickness(Tmax),and maximum area in transection (Smax)were observed before and after treatment in the two groups.Results There was no significant difference in the level of IL-6,CRP,TNF-α,IMT,Tmax or Smax between the two groups before treatment(P＞0.05）.After therapy,IL-6,CRP,and TNF-α levels,IMT,Tmax and Smax were all lower than those in the same group before treatment.After treatment,the levels of IL-6,CRP,TNF-α,IMT,Tmax,and Smax were all lower in the observation group compared with those in the control group with statistical significance(P＜0.05）.Conclusion The application of Buchang Naoxintong in patients with MHD can improve the inflammatory state and reduce the carotid intima-media thickness,which is worthy of clinical promotion.
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| [1] |
Mostaza JM，Lahoz C，Salinero-Fort MA，et al.Carotid atherosclerosisseverityinrelationtoglycemicstatus：across-sectional population study[J].Atherosclerosis，2015，242（2）：377-382.
|
| [2] |
王银娜，王英，贾艳丽，等.维持性血液透析患者血清sTWEAK水平与冠状动脉钙化的相关性研究[J].现代生物医学进展，2015，15（8）：1514-1517.
|
| [3] |
Umata T.Involvement of reactive oxygen species in stimuliinduced shedding of heparin-binding epidermal growth factor-like growth factor[J].J Uoeh，2014，36（2）：105-114.
|
| [4] |
王秀艳，赵惠荣，郭晶，等.颈动脉内膜-中层厚度、血清超敏C反应蛋白水平与老年人认知功能障碍的相关性研究[J].临床神经病学杂志，2014，27（3）：193-195.
|
| [5] |
Riccioni G.The effect of antihypertensive drugs on carotid intima media thickness：an up-to-date review[J].Curr Med Chem，2009，16（8）：988-996.
|
| [6] |
周娲，邹宏昌，杨丽萍，等.维持性血液透析患者血清胱抑素C、微炎症状态、颈动脉内膜中层厚度间的关系[J].山东医药，2013，53（1）：21-23.
|
| [7] |
Wang JG，Staessen JA，Li Y，et al.Carotid intima-media thickening and antihypertensive treatment a meta-analysis of randomized controlled trials[J].Stroke，2006，37（7）：1933-1940.
|
| [8] |
马世兴，陈卫红.益肾活血汤辅助治疗对维持性血液透析患者颈动脉内膜中层厚度、氧化应激指标及微炎症状态的影响[J].辽宁中医药大学学报，2017，19（12）：121-123.
|
| [9] |
Tian J，Hou X，Hu L，et al.Efficacy comparison of atorvastatin versus rosuvastatin on blood lipid and microinflammatory state in maintenance hemodialysis patients[J].Ren Fail，2017，39（1）：153-158.
|
| [10] |
陶瑾.维持性血液透析患者微炎症状态的临床研究[J].中国现代医学杂志，2014，24（4）：84-87.
|
| [11] |
Kuragano T，Itoh K，Shimonaka Y，et al.Hepcidin as well as TNF-α are significant predictors of arterial stiffness in patients on maintenance hemodialysis[J].Nephrol Dial Transplant，2011，26（8）：2663-2667.
|
| [12] |
李凡，郑劲，熊维建，等.帕罗西汀治疗维持性血液透析患者合并抑郁症的疗效[J].重庆医学，2014，43（25）：3296-3298.
|
| [13] |
Kuragano T，Shimonaka Y，Kida A，et al.Determinants of hepcidin in patients on maintenance hemodialysis：role of inflammation[J].Am J Nephrol，2010，31（6）：534-540.
|
| [14] |
高丽华，赵海鹰，孙宇，等.黄芪注射液对维持性血液透析患者氧化损伤状况的影响[J].广东医学，2016，37（5）：762-765.
|
| [16] |
钟建，赵宁博.益肾活血方联合氯沙坦对维持性血液透析患者内源性硫化氢及炎症细胞因子的影响[J].中国实验方剂学杂志，2015，21（2）：196-199.
|
| [15] |
Zhang J，Hua G，Zhang X，et al.Regulatory T cells/T-helper cell 17 functional imbalance in uraemic patients on maintenance haemodialysis：a pivotal link between microinflammation and adverse cardiovascular events[J].Nephrology（Carlton），2010，15（1）：33-41.
|
|
|
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