血浆D-二聚体及凝血指标在肝硬化和肝癌患者中的应用价值研究

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Abstract Objective To explore the value of plasma D-dimer and coagulation index in patients with liver cirrhosis and liver cancer.Methods A total of 50 patients with cirrhosis,50 patients with hepatocellular carcinoma and 50 healthy volunteers who underwent physical examination in our hospital from January 2015 to December 2017 were selected and set as liver cirrhosis group,liver cancer group and control group,all patients and the subjects were collected blood samples,the plasma D-dimer,coagulation parameters (prothrombin time,activated partial thromboplastin time,thrombin time)were detected,plasma D-dimer and coagulation index were compared between cirrhosis group,liver cancer group and control group.According to the Child-Pugh grading standard of liver reserve function,patients with cirrhosis were divided into A,B,C,and D-dimer and blood coagulation index in different Child-Pugh classification cirrhosis patients were compared.Pearson correlation coefficient analysis was used to analyze the correlation between plasma D-dimer,coagulation index and liver cirrhosis,liver cancer.Results The level of plasma D-dimer in the liver cancer group was higher than the liver cirrhosis group and the control group,the difference was statistically significant(P＜0.05）.The level of D-dimer in the liver cirrhosis group was higher than the control group,the difference was statistically significant(P＜0.05）.PT， APTT and the TT in the liver cancer group were lower than the liver cirrhosis group and the control group,the differences were statistically significant(P＜0.05）.PT,APTT and TT in the liver cirrhosis group were all lower than the control group,and the differences were statistically significant(P＜0.05）.The level of plasma D-dimer in Child-Pugh A patients was lower than grade B and C,and the differences were statistically significant(P＜0.05）.The level of D-dimer in Child-Pugh B patients was lower than grade C,and the difference was statistically significant(P＜0.05）.PT,APTT and TT in Child-Pugh A patients were higher than grade B and C,and the differences were statistically significant(P＜0.05）.PT,APTT and TT in Child-Pugh B patients were higher than grade C,and the differences were statistically significant(P＜0.05).Plasma D-dimer and cirrhosis,liver cancer were positively correlated,and coagulation indicators and cirrhosis,liver cancer were negatively correlated (P＜0.05).Conclusions Plasma D-dimer and coagulation index of patients with liver cirrhosis and liver cancer are different from those of normal people,plasma D-dimer and coagulation index can be used clinically to evaluate liver function and coagulation function in patients with liver cirrhosis and liver cancer index.

Key words： Cirrhosis Liver cancer D-dimer Coagulation function

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	CHEN Xiao-min
	LU Jian-xin

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CHEN Xiao-min,LU Jian-xin. Study on the value of plasma D-dimer and coagulation index in patients with liver cirrhosis and liver cancer[J]. 中国当代医药, 2018, 25(21): 46-48.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I21/46

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