血清淀粉样蛋白A、肝素结合蛋白与脓毒症严重程度的相关性分析

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Abstract Objective To explore the correlation between serum amyloid A(SAA),heparin binding protein(HBP)and the severity of sepsis.Methods 120 cases of patients with sepsis who treated in our hospital from November 2015 to January 2018 were selected as the case group,and they were divided into the sepsis group (48 cases),the severe sepsis group(40 cases)and the septic shock group(32 cases)according to the severity degree of the disease.At the same time,40 cases of health examination in our hospital were selected as the control group.The levels of SAA and HBP in the each group were compared and the correlation with the severity of sepsis was analyzed.Results The levels of serum SAA and HBP in the case group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of serum SAA and HBP in the severe sepsis group and the septic shock group were higher than those in the sepsis group,and the differences were statistically significant(P<0.05).The levels of serum SAA and HBP in the septic shock group were higher than those in the severe sepsis group,and the differences were statistically significant(P<0.05).Pearson correlation analysis showed that serum SAA and HBP were positively correlated with the severity of sepsis (r=0.752,0.794,P<0.05).Conclusion The serum levels of SAA and HBP are positively correlated with the severity of sepsis.The level of serum SAA and HBP are closely monitored in patients with sepsis which can be used to understand the severity of sepsis,and it is worthy of clinical promotion and application.

Key words： Serum amyloid A Heparin binding protein Sepsis Correlation analysis

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	LI Shou-wei

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LI Shou-wei. Correlation analysis of serum amyloid A,heparin binding protein and the severity of sepsis[J]. 中国当代医药, 2018, 25(15): 127-129.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I15/127

[1]	中华医学会重症医学分会.中国严重脓毒症/脓毒性休克治疗指南（2014）[J].中华内科杂志，2015，54（6）：401-426.
[2]	严静.中国严重脓毒症/脓毒性休克治疗指南（2014）：规范与实践[J].中华医学信息导报，2015，30（11）：19.
[3]	师灵灵，韩艳秋，任慧娟，等.脓毒症的病理生理机制研究进展[J].中华医院感染学杂志，2016，26（8）：1914-1916.
[4]	朱明燕，王燕，王毓，等.血清淀粉样蛋白A经p38-MAPK/SR-BI途径促进巨噬细胞炎症反应[J].生理学报，2016，68（3）：293-300.
[5]	钱定良，闫绍荣，潘晓荷.肝素结合蛋白和降钙素原及C反应蛋白在脓毒症早期诊断中的价值比较[J].中华检验医学杂志，2017，40（6）：451-455.
[6]	高戈，冯喆，常志刚，等.2012国际严重脓毒症及脓毒性休克诊疗指南[J].中华危重病急救医学，2013，25（8）：501-505.
[7]	中国中西医结合学会急救医学专业委员会.脓毒症中西医结合诊治专家共识[J].中华危重病急救医学，2013，25（4）：194-197.
[8]	曾文美，毛璞，黄勇波，等.脓毒症预后影响因素分析及预后价值评估[J].中国中西医结合急救杂志，2015，22（2）：118-123.
[9]	李立斌，严静.脓毒症的生物标记物：过去、现在和将来[J].中华急诊医学杂志，2013，22（9）：954-956.
[10]	薛庆亮，贾金虎，刘杜姣.脓毒症与炎性因子的研究进展[J].临床肺科杂志，2015，20（2）：335-336.
[11]	谢春明，刘宏锋.血清淀粉样蛋白A对急诊脓毒症患者诊断的意义[J].岭南现代临床外科，2015，15（4）：504-506.
[12]	范冬梅，李发红，钟丽，等.SAA、CRP联合检测在孕妇脓毒症诊断中的意义[J].中国社区医师，2016，32（5）：136-137.
[13]	Arnon S，Litmanovitz I，Regev RH，et al.Serum amyloid A：an early and accurate marker of neonatal early-onset sepsis[J].J Perinatol，2007，27（5）：297-302.
[14]	Fendler WM，Piotrowski AJ.Procalcitonin in the early diagnosis of nosocomial sepsis in preterm neonates[J].J Paediatr Child Health，2008，44（3）：114-118.
[15]	王亮，马晓春.肝素结合蛋白的结构和功能特点及其在脓毒症中的作用[J].中华危重病急救医学，2014，26（3）：200-203.
[16]	张扬，张慧，马慧霞.肝素结合蛋白研究进展[J].国际检验医学杂志，2015，36（19）：2869-2872.
[17]	许程，徐元宏.肝素结合蛋白在脓毒症诊断中的临床应用价值[J].中国现代医学杂志，2015，25（32）：59-62.
[18]	任玮，吴淼，魏捷，等.血浆肝素结合蛋白在脓毒性休克中的研究及应用进展[J].中华检验医学杂志，2017，40（7）：548-551.
[19]	张扬.血清肝素结合蛋白对脓毒症早期诊断价值的临床研究[D].乌鲁木齐：新疆医科大学，2016.
[20]	孙玲玲，蔡国龙，严静.肝素结合蛋白与感染相关的研究进展[J].中华重症医学电子杂志，2017，3（2）：148-152.