丙硫氧嘧啶与甲巯咪唑治疗甲状腺功能亢进症的临床效果比较

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Abstract Objective To analyze the clinical effects of Propylthiouracil and Methimazole in the treatment of hyperthyroidism.Methods A total of 80 hyperthyroidism patients admitted to our hospital from April 2015 to March 2016 were selected as research objects,and were divided into control group and research group by random number table method,with 40 cases in each group.The control group was treated with Propylthiouracil,while the study group was treated with Methylimidazole.The total effective rate,thyroid hormone indicators,clinical indicators,liver injury incidence,rash incidence and granulocyte damage rate of the two groups were compared.Results The total effective rate of patients in the study group was higher than that in the control group,and the difference was statistically significant(P<0.05).The thyroid hormone index of patients in the study group was better than that of the control group,and the difference was statistically significant(P<0.05).The clinical indicators of patients in the study group were better than those in the control group,with statistical significance (P<0.05).The incidence of liver injury in the study group was lower than that in the control group,and the difference was statistically significant(χ2=12.462,P=0.000).There was no significant difference in the incidence of adverse reactions between the two group(χ2=0.857,P=0.355).Conclusion In the clinical treatment of patients with hyperthyroidism,both Propylthiouracil and Methimazole have a certain therapeutic effect,but the latter treatment effect is significantly higher than the former,the latter in improving the thyroid hormone index,clinical indicators are excellent in the former,it is worthy of clinical application.

Key words： Formazan Propylthiouracil Methimazole Therapeutic effect

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	DENG Li-ping
	WU Hong-mei
	YUE You-wei

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DENG Li-ping,WU Hong-mei,YUE You-wei. Comparison of clinical efficacy of Propylthiouracil and Methimazole in the treatment of hyperthyroidism[J]. 中国当代医药, 2018, 25(15): 61-63转67.

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