糖皮质激素联合环磷酰胺治疗重症系统性红斑狼疮的效果

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Abstract Objective To investigate the clinical effect of Glucocorticoid and Cyclophosphamide in the treatment of severe systemic lupus erythematosus.Methods From July 2015 to July 2017,98 patients with severe systemic lupus erythematosus were selected as the subjects,and randomly divided into study group and control group,with 49 cases in each group.The control group was treated with Glucocorticoid,while the study group was treated with Glucocorticoid and Cyclophosphamide.The changes of SLEDAI score,ANA,ds-DNA,complement C3,immunoglobulin(IgG),urinary protein,blood creatinine(SCr)and blood urea nitrogen(BUN)were recorded before and after treatment.And the adverse reactions were compared between the two groups.Results After treatment,the indexes of the two groups were significantly improved(P＜0.05).The improvement of SLEDAI ANAds-DNA and IgG levels in the study group were significantly better than that in the control group,the improvement of the indexes of renal functions were also better than that of the control group (P＜0.05).There was no significant difference in the adverse reaction between the two groups (P＞0.05).Conclusion The combination of Glucocorticoid and Cyclophosphamide in the treatment of severe systemic lupus erythematosus can control the disease more effectively,improve the renal function of the patient,improve the clinical treatment effect,which has good safety and is worthy of clinical popularization.

Key words： Glucocorticoid Cyclophosphamide Systemic lupus erythematosus Clinical effect

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	YU Jing

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YU Jing. Effect of Glucocorticoid combined with Cyclophosphamide in the treatment of severe systemic lupus erythematosus[J]. 中国当代医药, 2018, 25(10): 44-46.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I10/44

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