肝细胞癌患者行根治外科疗法后的生存状况研究

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Abstract Objective To explore the survival status of patients with hepatocellular carcinoma after radical surgery in order to analyze the prognostic factors and provide direction and basis for clinical treatment of hepatocellular carcinoma.Methods The clinical data of 146 patients with hepatocellular carcinoma undergone surgical treatment from June 2008 to June 2012 in the central hospital(because these surgeons still worked in the Central Hospital of Huizhou)were retrospectively analyzed.All cases were followed up for 5 years after operation.All related factors were analyzed by single factor analysis,after that the Cox regression multiple-factor analysis was carried out if the index was statistically significant after single factor analysis.Results All the participants were successfully performed.Eighty cases were performed with anatomical hepatectomy,and the rest cases were not.Postoperative complications occurred in 10 patients,including pleural effusion(4 cases),incisional infection(2 cases),postoperative fever(2 cases),and intestinal obstruction(2 cases).A-mong them,some patients had multiple complications.After 5-year follow-up,the follow-up was from 1 to 139 months,and the median survival time was 59 months.The total survival rate of 5 years was 47.95% (70/146),and 3 cases were lost accounting for 2.05%.Univariate analysis showed that gender,age,grade of liver function,hepatic portal occlusion,and surgical mode were not related factors influencing on the survival state of patients with hepatocellular carcinoma after radical surgery therapy(P＞0.05).The related factors were tumor capsule,aspartate aminotransferase,microvascular invasion,tumor size,amount of tumor,tumor differentiation,total cholesterol,and AJCC stage(P＜0.05).Multivariate regression analysis displayed that tumor differentiation,microvascular invasion,tumor size,tumor number,and AJCC stage were independent factors that affected the survival status of patients with hepatocellular carcinoma after radical surgery(P＜0.05).Conclusion Both anatomical liver resection and non-anatomical liver resection for the treatment of patients with hepatocellular carcinoma have better long-term effects.Tumor differentiation,microvascular invasion,tumor size,number of tumor,and AJCC stage are independent factors influencing on the survival status of patients with hepatocellular carcinoma after radical surgery.

Key words： Hepatocellular carcinoma Radical surgical treatment Survival status

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	Articles by authors
	YUAN Bo
	LIAO Jin-qi
	FANG Yong-ping

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YUAN Bo,LIAO Jin-qi,FANG Yong-ping. Research on the survival status of patients with hepatocellular carcinoma after radical surgical treatment[J]. 中国当代医药, 2018, 25(10): 13-15.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I10/13

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