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| Efficacy of Tiotropium Bromide combined with noninvasive ventilator treating COPD complicated with typeⅡrespiratory failure and its influence on serum TNF-α,IL-27,CRP and oxygenation function of patients |
| LYU Jun1 LIU Xu1 ZHANG Ji-xian2▲ |
1.Department of Emergency,Hubei Provincial Hospital of Integrated Traditional Chinese and Western Medicine,Hubei Province,Wuhan 430015,China;
2.Department of Respiratory,Hubei Provincial Hospital of Integrated Traditional Chinese and Western Medicine,Hubei Province,Wuhan 430015,China |
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Abstract ObjectiveTo explore the efficacy of Tiotropium Bromide combined with non-invasive ventilation treating COPD complicated with typeⅡrespiratory failure and its influence on the inflammatory marker and oxygenation function of patients.Methods Ninety patients admitted into our hospital due to COPD from June 2014 to February 2016 were included in the study,and they were grouped using the random number table method.Forty-five patients in the control group were given Tiotropium Bromide,while 45 patients in the obeservation group were combined with noninvasive ventilator,and 7 days were a course of treatment.The improvement of blood gas index and inflammatory factors before and after treatment in patients between the two groups was compared,and the clinical efficacy between the two groups was compared.Results Before treatment,there were no statistically significant differences between the two groups in any indicators(P＞0.05).After treatment,PaO2and PaO2/FiO2were higher,and PaCO2was lower in the observation group than that in the control group (P＜0.05).TNF-α,IL-27 and CRP level were lower in the observation group than that in the control group (P＜0.05).The total effective rate of the observation group was 91.11%,which was higher than that of the control group 73.33% (P＜0.05).Conclusion The effect of Tiotropium Bromide combined with noninvasive ventilator treating COPD complicated with typeⅡrespiratory failure is obvious and can better improve oxygenation function and inflammation reaction.It is worth popularizing.
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| Cite this article: |
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LYU Jun,LIU Xu,ZHANG Ji-xian. Efficacy of Tiotropium Bromide combined with noninvasive ventilator treating COPD complicated with typeⅡrespiratory failure and its influence on serum TNF-α,IL-27,CRP and oxygenation function of patients[J]. 中国当代医药, 2018, 25(7): 34-37.
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| URL: |
| http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I7/34 |
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