右美托咪定预防小儿扁桃体切除术后苏醒期躁动及其血流动力学反应的临床研究

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Abstract Objective To investigate the effect of Dexmedetomidine on emergence agitation and hemodynamic responses in pediatric patients.Methods From August 2013 to Apri1 2015,Yemen Hudaydah Revo1ution Hospita1,50 pediatric patients undergoing e1ective tonsi11ectomy,were random1y a11ocated to dexmedetomi dine group（group D,n＝25）and contro1 group（group C,n＝25）.After anesthetic induction,group D was given the Dexmedetomidine 0.5 μg/kg,intravenous injection during 10 minutes,group C was given the same capacity of 0.9％norma1 sa1ine intravenous injection during 10 minutes.Parameters records inc1uding time of trachea1 extubation and out of operating theatre;riker ca1mrest1ess score; noninvasive heart rate（HR）,systo1ic b1ood pressure（SBP）and diasto1ic b1ood pressure（DBP）before anesthetic induction（T0）and before（T1）and after trachea1 extubation（T2）;rate-pressure product（RPP）were ca1cu1ated.Results There was no difference in time of trachea1 extubation and out of operating theatre（P＞0.05）;riker ca1mrest1ess score in group D was significant1y better than group C,there was significant difference（P＜0.05）;the SBP,DBP,HR and RPP compared preinduction（T0）with before（T1）and after（T2）trachea1 extubation in group D, there were no significant differences（P＞0.05）;the SBP,DBP,HR and RPP compared preinduction（T0）with before（T1）and after（T2）trachea1 extubation in group C,there were significant differences（P＜0.05）.In group D,SBP,DBP,HR and RPP at T1and T2were significant 1ower than those in group C with significant differences（P＜0.05）.Conclusion Dexmedetomidine can reduce the occurrence of emrgence agitation and hemodynamic responses in pediatric patients undergoing tonsi11ectomy.

Key words： Dexmedetomidine Pediatric patients Emergence agitation Hemodynamic response

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	Articles by authors
	WANG Wei-hua
	LI Ya-rong
	SONG Quan-hong3

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WANG Wei-hua,LI Ya-rong,SONG Quan-hong3. Clinical research of Dexmedetomidine for prevention of emergence agitation and hemodynamic responses in pediatric patients undergoing tonsillectomy[J]. 中国当代医药, 2016, 23(5): 98-100.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I5/98

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