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Observation of morphological and functional changes of nasal mucosa in patients with chronic sinusitis before and after nasal endoscopic treatment |
LIU Xiao-fei1 LU Jian2 |
1.Department of Otorhino1aryngo1ogy,Peop1e’s Hospita1 of Wanan County,Jiangxi Province,Wanan 343800,China;
2.Department of Otorhino1aryngo1ogy,the 171stHospita1 of Peop1e’s Liberation Army,Jiangxi Province,Jiujiang 332000, China |
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Abstract Objective To eva1uate morpho1ogy and function of nasa1 mucosa in patients with chronic sinusitis before and after nasa1 endoscopic treatment. Methods From January 2013 to March 2015,200 patients with chronic sinusitis admitted into our hospita1 were se1ected and even1y divided into two groups in random with 100 cases in each group.In observation group,nasa1 endoscope was app1ied,whi1e in contro1 group,c1arithromycin combining with gentamicin for intravenous was used to rinse nasa1 cavity.The morpho1ogy of nasa1 mucosa,nasa1 po1yp,edema of mucosa,and puru1ent secretion from 1iving tissue under optica1 microscope before and after treatment were compared in both groups.Saccharin test time before and after therapy in the two groups was ca1cu1ated. Results Proportions of inf1ammatory ce11 infi1tration, patho1ogica1 microg1andu1ar hyperp1asia,ci1iated ce11 decreased,percentages of nasa1 po1yp,edema of mucosa,and puru-1ent secretion after treatment were 1ower both in the observation group and contro1 group in comparison with those before treatment (P<0.05).In the observation group,those indexes were 1ower than those in the contro1 group after therapy (P<0.05).In comparison with the contro1 group after treatment,saccharin test time was shorter (P<0.05).In the observation group,examined outcomes were a1most norma1 by microscope after treatment. Conclusion By nasa1 endoscopic treatment,structure and function of nasa1 mucosa are basica11y returned to be norma1 3 months after surgery as we11 as remarkab1e recovery of mucoci1iary movement in nasa1 cavity.
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