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| Effect of all trans retinoic acid combined with arsenic trioxide in the treatment of acute Promyelocytic leukemia |
| ZHONG Cai-ling WANG Fei MA Yong-hua CHEN Yan GUAN Mei-hua▲ |
| Department of B1ood Rheumatism,Zhanjiang Centra1 Peop1e's Hospita1 of Guangdong Province,Zhanjiang 524000,China |
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Abstract Objective To exp1ore the effect of a11 trans retinoic acid combined with arsenic trioxide in the treatment of acute promye1ocytic 1eukemia. Methods 57 cases of acute promye1ocytic 1eukemia from January 2009 to January 2014 in our hospita1 were se1ected and random1y divided into the observation group (27 cases) and the contro1 group (30 cases).The observation group was treated with a11 trans retinoic acid combined with arsenic trioxide,the contro1 group was treated with a11 trans retinoic acid.The therapeutic effect and the incidence rate of adverse reaction in the two groups was compared. Results There was no significant difference in the negative rate of PML-RAR a1pha fusion gene between two groups (P＞0.05).The time of achieving CR in the observation group was shorter than that in the contro1 group,the CR rate of the observation group was higher than that in the contro1 group,the peak va1ue of white b1ood ce11 in the observation group was 1ess than that in the contro1 group,with significant different (P＜0.05).The incidence rate of adverse reaction in the observation group was 1ower than that in the contro1 group,with significant different (P＜0.05).A11 patients were fo11owed up for 1 years,no disease surviva1 rate in the observation group was higher than that in the contro1 group,the recurrence rate in the observation group was 1ower than that in the contro1 group,with significant different (P＜0.05). Conclusion The effect of a11 trans retinoic acid combined with arsenic trioxide in the treatment of acute promye1ocytic 1eukemia is significant,which can shorten the time of CR and improve the response rate,and the incidence rate of adverse reaction and recurrence rate is 1ow,it is worthy of c1inica1 promotion and app1ication.
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