子宫内膜异位症保守性手术联合药物巩固后复发者应用左炔诺孕酮宫内缓释系统的疗效观察

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Abstract Objective To explore the application effect of levonorgestrel-releasing intrauterine system　（LNG-IUS）in patients with recurrent endometriosis after treatment of conservative operation combined with drug.Methods 68 patients with recurrent endometriosis after treatment of conservative operation combined with drug in our hospital from May 2011 to July 2014 were selected as the research group，all patients were given LNG-IUS for treatment and followed up for 12 months，the therapeutic effect was observed.Results The score of VAS，the level of serum CA125 at 3，6，12 months after placement of LNG-IUS was lower than that before placement of LNG-IUS，the level of hemoglobin at 3，6，12 months after placement of LNG-IUS was higher than that before placement of LNG-IUS，with significant difference　（P＜0.05）.The volume of pelvic mass at 6，12 months after placement of LNG-IUS was less than that before placement of LNG-IUS，with significant difference（P＜0.05）.After placement of LNG-IUS，with the increase in placement time，the endometrial thickness were gradually thinning，menstrual volume was gradually reduced，compared with the before placement，the difference was statistically significant（P＜0.05）.The incidence rate of intermenstrual bleeding after treatment of LNG-IUS at 3 months was 66.2%.The incidence rate of adverse reaction such as bearing-down pain，intermenstrual bleeding，and facial pigmentation were gradually reduced along time，the difference was statistically significant（P＜0.05）.The incidence rate of amenorrhoea and LNG-IUS fall-off was low，there was no significant difference in different time periods（P＞0.05）.Conclusion LNG-IUS has favorable effect in patients with postoperative recurrent endometriosis，it is worthy of clinical promotion and application.

Key words： Endometriosis Postoperative recurrence Levonorgestrel intrauterine sustained release system Therapeutic effect

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	Articles by authors
	WU Hong-juan
	LIU Guang-zhen
	KONG Min-li

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WU Hong-juan,LIU Guang-zhen,KONG Min-li. Effect observation of the use of levonorgestrel-releasing intrauterine system in the treatment of recurrence of endometriosis after consolidation of conservative surgery combined with drug[J]. 中国当代医药, 2016, 23(10): 105-107.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I10/105

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