改良尿激酶静脉溶栓法治疗急性脑梗死的效果观察

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Abstract Objective To investigate the possibility of the improved intravenous thrombolytic therapy for the acute cerebral infarction with urokinase.Methods 56 cases of patients with acute cerebral infarction from January 2013 to March 2014 were randomly divided into traditional urokinase thrombolysis group　（quick delivery）with 28 cases and improved urokinase thrombolysis group（slow delivery）with 28 cases.The traditional urokinase thrombolysis group was given conventional intravenous thrombolytic therapy with urokinas，and the improved urokinase thrombolysis group was given improved intravenous thrombolytic therapy with urokinase.The clinical effect of two groups were compared.Results NIHSS scores of the treatment group were significantly decreased after using urokinase at 3，7，14，30 d　（P＜0.05）.BI scores of the treatment group were significantly increased after 7，14 d　（P＜0.05）.The total effective rate in the improved urokinase thrombolysis group was 92.86%，which was higher than 82.14%of the traditional urokinase thrombolysis group，and the difference were statistically significant（P＜0.05）.The security was increased significantly in modified urokinase thrombolysis group compared with that in traditional urokinase thrombolysis group.Conclusion The improved intravenous thrombolytic therapy for acute cerebral infarction is a kind of safe and effective method.

Key words： Acute cerebral infarction Urokinase thrombolysis Nervous function defection and damage grade score Barthel index

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	Articles by authors
	YIN Yao-hui
	HUANG Shu-yi
	SHEN Wei-bing
	LU Ping-hua
	LU Chao
	LIN Jia-qing
	YE Shao-hui

Cite this article:

YIN Yao-hui,HUANG Shu-yi,SHEN Wei-bing, et al. Effect observation of the improved intravenous thrombolytic therapy for acute cerebral infarction with urokinase[J]. 中国当代医药, 2016, 23(10): 55-58.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I10/55

［1］	习秀霞，刘煜敏.急性脑梗死溶栓治疗的研究进展［J］.国际脑血管疾病杂志，2009，17（7）：549-553.
［2］	陶先明，胥明，谢勇.尿激酶超早期溶栓治疗急性脑梗死40例疗效观察［J］.重庆医学，2011，40（19）：1938-1939.
［3］	Nakashima T，Minematsu K.Prospects of thrombolytic therapy for acute ischemic stroke［J］.Brain Nerve，2009，61（9）：1003-1012.
［4］	Murao K，Leys D，Jacquin A.Thrombolytic therapy for stroke in patients with pre-existing cognitive impairment［J］.Neurology，2014，14（10）：493.
［5］	Mehrpour M，Aghaei M，Motamed MR.Safety and feasibility of intravenous thrombolytic therapy in Iranian patients with acute ischemic stroke［J］.Med J Islam Repub Iran，2013，27（3）：113-118.
［6］	陈其元，严严，王建明.不同时间窗进行脑梗死溶栓治疗的疗效及安全性观察［J］.实用临床医药杂志，2011，15（5）：91-92.
［7］	全国第四届脑血管病学术会议.脑卒中患者临床神经功能缺损程度评分标准［J］.中华神经科杂志，1996，29（6）：381.
［8］	Lanitis T，Cotté F，Gaudin A.Stroke prevention in patients with atrial fibrillation in France：comparative cost-effectiveness of new oral anticoagulants（apixaban，dabigatran and rivaroxaban），warfarin and aspirin［J］.J Med Econ，2014，15（1）：30-31.
［9］	Marián MD，Marta R，David RL，et al.Baseline national institutes of health stroke scale-adjusted time window for intravenous tissue-type plasminogen activator in acute ischemic stroke［J］.Stroke，2014，45（1）：1059-1063.
［10］	Liesbet DW，Koen P，Hannes D，et al.Long-term prediction of functional outcome after stroke using single items of the Barthel Index at discharge from rehabilitation centre［J］.Disabil Rehabil，2014，36（5）：353-358.
［11］	Bandera E，Botterri M，Minelli C，et al.Cerebral blood flow threshold of ischemic punumbra and infarct core in acute ischemic stroke：a systematic review［J］.Stroke，2006，37（5）：1334-1339.
［12］	中华医学会神经病学分会脑血管病学组急性缺血性脑卒中诊治指南撰写组.中国急性缺血性脑卒中诊治指南2010［J］.中华神经科杂志，2010，43（1）：146-153.
［13］	Jauch EC，Saver JL，Adams HP，et al.Guidelines for the early　managementofpatientswith　acute　ischemic stroke：a guideline for health care professionals from the American Heart Association/American Stroke Association［J］.Stroke，2013，44（1）：870-947.
［14］	贺茂林，陈清棠.急性脑梗死的溶栓治疗时间窗及其病理生理［J］.中国危重病急救医学，2000，12（5）：315-317.
［15］	Yamaguchi T，Mori E，Minematsu K，et al.Alteplase at 0.6 mg/kg for acute ischemic stroke within 3 hours of onset：Japan Alteplase Clinical Trial（J-ACT）［J］.Stroke，2006，37（7）：1810-1815.
［16］	孟然，吉训明，周晋，等.脑梗死患者溶栓前后血浆纤维蛋白原水平与早期脑梗死的关系［J］.中国脑血管病杂志，2008，5（7）：289-292.