乳腺癌淋巴细胞亚群与不同分子亚型及临床病理特征的意义研究

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Abstract Objective To detect the changes of peripheral blood lymphocyte subsets in patients with different subtypes of breast cancer，and explore the relationship between different subtypes of breast cancer and their clinical pathological characteristics. Methods A total of 206 patients with women breast disease were selected from January to December 2013 in Affiliated Tumor Hospital of Guangxi Medical University，and were randomly divided into for 166 cases of patients with breast cancer group（observation group，n = 166）and 40 cases of healthy people as normal healthy group （control group，n = 40）.Immunohistochemistry envision two-step was used to detect the expression of estrogen receptor （ER），progesterone receptor（PR），human epidermal growth factor receptor-2（HER-2）and Ki-67，using flowcytometry to detect the two group the of peripheral blood lymphocyte subgroup of CD3+，CD4+，CD8+，CD16+CD56+，CD19+activity，combined with the clinical and pathological features were analyzed and compared. Results Compared with the normal healthy group，the percentage of CD3+and CD4+/CD8+was significantly decreased in the groups of Luminal A，Luminal B type and HER-2 over expression（P＜0.05）.In the four kinds of molecular subtypes，the activity of CD4+and CD19+was significantly decreased compared with the normal healthy group（P＜0.05）.The activity of NK（CD16+CD56+）of triple negative was significantly decreased compared with the normal healthy group（P＜0.05）；Histological gradeⅡhad a significantly lower activity of CD4+than the group of histology gradeⅠ（34.35±9.03 vs 38.12±8.75，P＜0.05）.The histological gradeⅢhad a significantly lower activity of NK（CD16+CD56+）than the histological gradeⅡ（13.92±6.34 vs （16.15±7.98，P＜0.05）.The activity of CD4+and CD4+/CD8+ratio in patients with lymph node metastasis were significantly lower than the patients without lymph node metastasis（P＜0.05）. Conclusion The determination of peripheral blood lymphocyte subsets in patients with different molecular subtypes of breast cancer patients has a certain significance in the state of immune function，which can contribute to the observation of the disease，curative effect monitoring and prognosis.

Key words： Breast cancer Lymphocyte subsets Molecular subtype Clinicopathology characteristics

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	Articles by authors
	WEI Chang-hong
	NING Shu-fang
	WEI Wen-e
	LI Ji-lin
	LIU Hai-zhou
	CHEN Yi
	ZHANG Li-tu

Cite this article:

WEI Chang-hong,NING Shu-fang,WEI Wen-e, et al. Significance of lymPhocyte subsets and molecular subtyPes of breast cancer and clinical Pathological characteristics[J]. 中国当代医药, 2016, 23(11): 8-11.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I11/8

［2］	Siegel R，Ma J，Zou Z，et al.Cancer statistics［J］.CA，2014， 64（1）：9-29.
［4］	Perou CM，Sorlie T，Eisen MB，et al.Molecular portraits of human breast tumours［J］.Nature，2000，406（6797）：747-752.
［1］	Redig AJ，McAllister SS.Breast cancer as a systemic disease：a view of metastasis［J］.J Intern Med，2013，274（2）：113-126.
［3］	Wang CH，Li JZ，Zhang W.Breast cancer molecular subtypes of Uygur and Han in Xinjiang of China［J］.Int J Clin Exp Med，2014，7（4）：1116-1121.
［5］	Hochest B，Diehl L.Antigen shedding into the circulation contributes to tumor immune escape［J］.Oncoimmunology，2012，1（9）：1620-1622.
［6］	秦颖，张同先，张巍，等.青年乳腺癌临床病理特点分子分型及预后分析［J］.中国肿瘤临床，2014，41（4）：231-236.
［7］	Witte E，Witte K，Warszawska K，et al.Interleukin -22：a cytokine produced by T，NK and NKT cell subsets，with importance in the innate immune defense and tissue protection［J］.Cytokine Growth Factor Rev，2010，21（5）：365-379.
［8］	张铁英，康丽花，刘远航，等.不同分子亚型乳腺癌T淋巴细胞和NK细胞检测的临床意义［J］.中国妇幼保健，2015，30（21）：3594-3595.
［9］	Rad FR，Ajdary S，Omranipour R，et al.Comparative analysis of CD4+and CD8+T cells in tumor tissues，lymph nodes and the peripheral blood from patients with breast cancer［J］. Iran Biomed J，2015，19（1）：35.
［10］	冀为，周岩，牛瑞芳.外周血T淋巴细胞亚群与不同分子分型乳腺癌患者无病生存的相关性研究［J］.中国肿瘤临床，2014，41（21）：1363-1367.
［11］	Tabariès S，Ouellet V，Hsu BE，et al.Granulocytic immune infiltrates are essential for the efficient formation of breast cancer liver metastases［J］.Breast Cancer Res，2015，17（1）：1-18.
［12］	孙林，温江涛，刘海红.乳腺癌患者外周血T淋巴细胞及NK细胞的检测及其临床意义［J］.现代肿瘤医学，2006，14（9）：1069-1071.
［13］	林志明，刘慧，高全立，等.乳腺癌患者外周血中调节性T细胞的表达及意义［J］.现代预防医学，2011，38（12）：2258-2260.
［14］	李永峰，吴云飞，张慧.淋巴结转移比率在预测淋巴结转移乳腺癌患者预后中的价值［J］.中国普外基础与临床杂志，2011，18（7）：750-754.
［15］	朱赤红，许沈华，凌雨田.乳腺癌外周血淋巴细胞亚群检测及其预后意义［J］.中国卫生检验杂志，2013，23（14）：2957-2960.
［16］	韦录，吴向华，刘金录，等.乳腺癌复发转移的相关分子生物学指标临床意义的研究［J］.广西医科大学学报，2012，29（2）：237-239.