ObjectiveTo investigate the clinical effect of early cranioplasty in the treatment of skull defect after traumatic brain injury.MethodsFrom August 2014 to March 2017,90 patients with skull defect after craniocerebral trauma treated in our hospital were selected as the research object,and they were randomly divided into observation group(n=45)and control group(n=45).The control group receivedadvanced cranioplasty,and the observation group received early cranioplasty.The clinical effect,the incidence of complications and satisfaction of the treatment were compared between the two groups.ResultsThe total effective rate of the observation group was 84.44%,which was significantly higher than that of the control group (62.22%),and the difference was statistically significant(P＜0.05).The total incidence of complications in the observation group was 6.67%,which was significantly lower than that of the control group (17.78%),and the difference was statistically significant(P＜0.05).The treatment satisfaction of the observation group was 93.33%,which was significantly higher than that of the control group(66.67%),and the difference was statistically significant(P＜0.05).ConclusionEarly cranioplasty has good clinical efficacy in the treatment of skull defect after traumatic brain injury,and can effectively reduce the incidence of adverse complications,which is suitable for further promotion in the clinical field.