七氟醚对老年食管癌患者的心肌保护作用

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Abstract Objective To investigate the myocardia1 protective effect of sevof1urane inha1ation anesthesia on perioperative period of e1der1y patients with propofo1 intravenous anesthesia.Methods 40 e1der1y patients who were given radica1 surgery for esophagea1 cancer in our hospita1 from March 2014 to March 2015 were se1ected.They were assigned to the group of inha1ation anesthesia with sevof1urane（group S）and the group of intravenous anesthesia with propofo1（group P）according to the random number tab1e，with 20 patients in each group.The cTnI 1eve1 and microRNA-499 and microRNA-208b 1eve1s at different time points were compared between the two groups of patients.Results①The contents of cTnI in group P at the T2，T3，T4was higher than that in group S respective1y，and the differences was statistica11y significant（P＜0.05）.②The contents of microRNA-499 and microRNA-208b at the T3in group P was higher than that in group S respective1y，and the differences was statistica11y significant（P＜0.05）.Conclusion Inha1ation anesthesia with sevof1urane has better myocardia1 protection effects than intravenous anesthesia with propofo1，and it has great significance in reducing the cardiac comp1ications in e1der1y patients during the perioperative period.

Key words： Sevof1urane Esophagea1 cancer Myocardia1 protection

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	Articles by authors
	LI Zhi-yi
	LIU Xiao-yan
	ZHANG Liang-qing
	CAI Wei-hua
	CHEN Shang-liang

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LI Zhi-yi,LIU Xiao-yan,ZHANG Liang-qing, et al. Myocardial Protection effects of sevoflurane on elderly Patients with esoPhageal cancer[J]. 中国当代医药, 2016, 23(14): 93-95.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I14/93

［1］	魏文强，杨娟，张思维，等.2004-2005年中国食管癌死亡情况及变化趋势［J］.中华预防医学杂志，2010，44（5）：398-402.
［2］	陈文虎.食管癌的综合治疗［J］.肿瘤，2003，23（2）：85-86.
［3］	Conzen PF，Fischer S，Detter C，et al.Sevof1urane provides greater protection of the myocardium than propofo1 in patients undergoing off-pump coronary artery bypass surgery ［J］.Anesthesio1ogy，2003，99（4）：826-833.
［4］	孙瑛，朱明，张剑蔚，等.七氟醚预处理和后处理对婴幼儿体外循环心肌再灌注损伤的影响［J］.上海交通大学学报（医学版），2011，31（9）：1316-1319.
［5］	王丹丹，杨程，崔苏扬.七氟醚吸入麻醉与丙泊酚复合七氟醚麻醉对血糖的影响［J］.临床麻醉学杂志，2009，25（12）：1049-1050.
［6］	周峰，何业伟.浅谈老年患者择期手术麻醉问题［J］.医学与哲学，2011，32（24）：19-21.
［7］	陈恒，黄标新.瑞芬太尼-七氟醚静吸复合麻醉在腹腔镜胆囊切除术的应用价值［J］.中国当代医药，2011，18（24）：79-80.
［8］	索爱军.七氟醚复合瑞芬太尼在门诊短小手术中的应用［J］.中国医学创新，2011，8（26）：47-48.
［9］	叶治，王锷，潘韫丹，等.线粒体ATP敏感性钾通道在七氟醚预处理减轻大鼠缺血再灌注损伤中的作用［J］.中华麻醉学杂志，2009，29（12）：1109-1112.
［10］	姚允秦，李立环.七氟醚和异丙酚对冠状动脉旁路移植术患者心肌保护作用比较的Meta分析［J］.中华麻醉学杂志，2012，31（7）：592-597.
［11］	马自梅.心肌肌钙蛋白I在急性心肌损伤诊断中的临床应用价值［J］.齐齐哈尔医学院学报，2012，33（6）：759-760.
［12］	Condore11i G，Latronico MV，Dorn GW 2nd.microRNAs in heart disease：putative nove1 therapeutic targets？［J］.Eur Heart J，2010，31（6）：649-658.
［13］	Gid1of O，Andersson P，van der Pa1s J，et al.Cardiospecific microRNA p1asma 1eve1s corre1ate with troponin and cardiac function in patients with ST e1evation myocardia1 infarction，are se1ective1y dependent on rena1 e1imination，and can be detected in urine samp1es［J］.Cardio1ogy，2011，118（4）：217-226.
［14］	Corsten MF，Dennert R，Jochems S，et al.Circu1ating MicroRNA-208b and MicroRNA-499 ref1ect myocardia1 damage in cardiovascu1ar disease［J］.Circ Cardiovasc Genet，2010，3（6）：499-506.
［15］	O1ivieri F，Antonice11i R，Lorenzi M，et al.Diagnostic potentia1 of circu1ating miR-499-5p in e1der1y patients with acute non ST-e1evation myocardia1 infarction［J］.Int J Cardio1，2013，163（2）：531-536.