艾司西酞普兰治疗老年抑郁症的效果及其对生活质量的影响

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Abstract Objective To understand the effectiveness of escitalopram in the treatment of elderly depression and its effects on life quality.Methods 60 outpatients and inpatients with elderly depression from October 2010 to October 2015 were randomly assigned to two groups，with 30 patients in each group.The two groups were given the treatment of escitalopram and citalopram respectively.HAMD was applied before the treatment，at the end of the first week，second week，fourth week，eighth week and twelfth week after the treatment to evaluate the curative effects，GQOLI-74 was applied to evaluate patients′life quality，and adverse reactions were observed.Results The differences of total scores of HAMD before the treatment in escitalpram group and citalpram group were not statistically significant（P＞0.05）；At the end of the first week until the twelfth week after the treatment，the total score of HAMD in both groups was gradually reduced respectively，and the difference compared with that before the treatment was statistically significant（P＜0.05）；At the end of the twelfth week，compared with citalpram group，the total score of HAMD in escitalpram group was reduced more greatly，and the difference between the two groups was statistically significant（P＜0.05）；Compared with the situation before the treatment，at the end of the twelfth week，physical function，mental function and social function in both groups was significantly improved respectively（P＜0.01）；At the end of the twelfth week，the improvement of physical function and social function in escitalpram group was better than that in citalpram group（P＜0.01）；The adverse reactions in both groups were slight.Conclusion Escitalpram is helpful for enhancing long-term curative effects and improving life quality in patients with elderly depression.

Key words： Escitalpram Elderly depression Life quality

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	Articles by authors
	LIU Lin-lin
	DUAN Ni
	WANG Dong-ming
	SUN Ping

Cite this article:

LIU Lin-lin,DUAN Ni,　WANG Dong-ming, et al. Curative effects of escitalopram in the treatment of elderly depression and its effects on life quality[J]. 中国当代医药, 2016, 23(17): 139-141转151.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I17/139

［1］	沈渔邨.精神病学［M］.5版.北京：人民卫生出版社，2010：586-589.
［2］	Alexopoulos GS，Borson S，Cuthbert BN et al.Assessment of late life depression［J］.Biol Psychiatry，2002，52（3）：164-174.
［3］	范肖冬，汪向东，于欣，等译.国际疾病分类第10版精神和行为障碍分类标准［M］.北京：人民卫生出版社，1993：97-104.
［4］	张明园.精神科评定量表手册［M］.长沙：湖南科学技术出版社，1993：121-126.
［5］	汪向东，王希林，马弘.心理卫生评定量表手册［M］.北京：中国心理卫生杂志社，2001，12（增刊）：74-81.
［6］	喻东山，高振忠.精神科合理用药手册［M］.南京：江苏科学技术出版社，2005：262-268.
［7］	刘文，李焕徳.新型抗抑郁药物的临床应用及其作用机制研究进展［J］.中国药房，2007，18（1）：66-68.
［8］	Mork A，Kreilgaard D，Sanchex C.The R-enantiomer of citalopram counteracls escitalopram-induced increase in extraceliular 5-HT in the frontal cortex of freely moring rats［J］. Nevropharmacology，2003，45（2）：167-173.
［9］	Baldwin DS.Escitalopram：efficancy and tolerabitity in the treatment of depression［J］.Hosp Med，2002，63（11）：668-671.
［10］	陈振林，于海鹏.艾司西酞普兰治疗老年抑郁症的临床疗效观察［J］.上海医药，2011，32（10）：490-491.
［11］	张爱娥.艾司西酞普兰治疗老年抑郁症临床疗效观察［J］.中国实用医药，2011，6（20）：162-163.
［12］	邱述领，王佳佳，周保卫.艾司西酞普兰治疗老年抑郁症的对照研究［J］.中国民康医学，2011，23（6）：664-665.
［13］	王东明，刘琳琳，刘锡亮，等.艾司西酞普兰治疗老年抑郁症的临床研究［J］.四川精神卫生，2010，23（2）：77-79.
［14］	伍海姗，常麦会，李乐华，等.艾司西酞普兰治疗抑郁症的疗效和安全性［J］.中国新药与临床杂志，2011，30（12）：907-911.
［15］	von Moltke LL，Greenblatt DJ，Giancarlo GM，et al.Escitalopram （S-citalopram）and its metabolites in vitro：cytochromes mediating biotransformation，inhibitory effects，and comparison to R-citalopram［J］.Drug Metab Dispos，2001，29（8）：1102-1109.