ObjectiveTo investigate the effect of comprehensive rehabilitation nursing on activities of daily living(ADL)in children with cerebral palsy(CP).MethodsA total of 73 with CP were recruited in our hospital from January 2013 to December.The subjects were then non-randomly allocated to a control group(n=28)who was subjected to an outpatient rehabilitation training and an intervention group(n=45)who receivedinpatient treatment.The control group was received a conventional rehabilitation training for 12 weeks,while the intervention group was received a conventional rehabilitation training as well as a comprehensive rehabilitation nursing care,which included diet,psychological,concomitant symptoms nursing and activities of daily living training.The scores of ADL were calculated and compared pre-treament and post-treatment in the two groups.ResultsThere was no difference in the scores of ADL between the two groups before treatment(P＞0.05).Compared to baseline,the scores of ADL for children with CP were significantly improved in both groups after treatment(P＜0.01）.But the scores after treatment in the intervention group were significantly higher than that of the control group(P＜0.01）.Conclusions Rehabilitation nursing intervention may be effective in improving ability of self-care and quality of life for children suffering from CP.