右美托咪定在急性冠脉综合征患者诱导期及维持的应用

Abstract
Figure/Table
References (15)
Related Citation (15)

Download: PDF (0 KB) HTML (36 KB)
Export: BibTeX | EndNote (RIS)

Abstract ObjectiveTo explore the safety and the effects of Dexmedetomidine on acute coronary syndrome patients during induction.Methods25 patientswith acute coronary syndromes who underwent surgery in our hospital from January to December 2015 were selected as experimental group,20 patientswith acute coronary syndromes from January to December 2014 were selected as control group.The patients in the experimental group were injected with 1μg/kg Dexmedetomidine for 15 minutes and then injected with 0.3μg/kg·h of the same volume of saline for 15 minutes,then Etomidate,Sufentanil,Vecuronium slowly induced intubation.Propofol and sufentanil were maintained by target-controlled infusion,and bispectral index (BIS)wasmaintained at 40 to 60.Blood pressure and heart rate were recorded at T1,T2,T3,and T4.Cortisol concentration wasmeasured by 3 ml blood collection.ResultsThe concentration of cortisol in experimental group was significantly lower than that of control group at T3and T4,and the heart rate at T1,T2and T3was slower than that of control group (P<0.05).Conclusion Dexmedetomidine can induce and maintain acute coronary syndrome,and the circulation ismore stable andmore effective in suppressingmyocardial stress response.

Key words： Dexmedetomidine Coronary syndrome Induction period

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHENGHai-tao
	SU Xin-juan
	HU Jie

Cite this article:

ZHENGHai-tao,SU Xin-juan,HU Jie. Application of Dexmedetom idine in the induction and maintenance of patientswith acute coronary syndrome[J]. 中国当代医药, 2016, 23(33): 120-122.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I33/120

[1]	RAmay Y，Abud B，Tekgul ZT，et al.Effects of dexmedetomidine and propofol on sedation in patients after coronary artery bypass graft surgery in a fast-track recovery room setting[J].JAnesth，2015，29（4）：522-528．
[2]	唐娜，陈丽.右美托咪定的临床研究进展[J].中国当代医药，2015，22（23）：19-21.
[3]	Sezen G，Demiraran Y，Seker IS，et al.Does premedication with dexmedetomidine provide perioperative hemodynamic stability in hypertensive patients?[J].BMC Anesthesiology，2014，14：113.
[4]	Xu L，Hu Z，Shen J，etal.Doesdexmedetomidine havea ardiac protective effect during non-cardiac surgery a randomised controlled trial[J].Clin Exp PharmacolPhysical，2014，41（11）：879-883.
[5]	刘宝伟，赵素贞.颅脑手术患者全麻中右美托咪定对皮质醇抑制程度和氧合指数的影响[J].中国实用神经疾病杂志，2016，19（13）：74-75.
[6]	薛国剑，郝建华.右美托咪定在心血管手术麻醉中的应用进展[J].新乡医学院学报，2016，33（1）：73-76.
[7]	Balkanay OO，Goksedef D，Omeroglu SN，et al.The dose-related effects of dexmedetomidine on renal functions and serum neutrophil gelatinase-associated lipocalin values after coronary artery bypass grafting：a randomized，triple-blind，placebocontrolled study[J].Interact Cardiovasc Thorac Surg，2015，20（2）：209-214.
[8]	Ji F，Li Z，Nguyen H，et al．Response to letters regarding article，"perioperative dexmedetomidine improves outcomes of cardiac surgery"[J].Circulation，2013，128（16）：e339-e340.
[12]	邵丽娜，白静慧.右美托咪定治疗快速性室上性心律失常1例[J].河北医药，2015，37（2）：319-320．
[13]	戴丽英.右美托咪定在临床麻醉中的应用[J].临床合理用药，2016，9（6）：90-91.
[14]	周宁，陈春龙，高珊，等.右美托咪定预防吗啡耐受及其对脊髓内胶质细胞和ERK的影响[J].中国药理学通报，2014，30（1）：96-100.
[15]	陈琦妮.不同剂量右美托咪定对全麻拔管患者的影响[J].广西医学，2014，36（2）：265-266．
[9]	Ren J，Zhang H，Huang L，etal.Protectiveeffectofdexmedetomidine in coronary artery bypass grafting surgery[J].Exp T-her Med，2013，6（2）：497-502.
[10]	Nasse JS，Travers JB．Adrenoreceptormodulation of oromotor pathways in the ratmedulla[J].JNeurophysiol，2014，112 （3）：580-593．
[11]	Wang XW，Cao JB，Lv BS，et al.Effect of perioperative dexmedetomidine on the endocrinemodulators of stress response：a meta-analysis[J].Clin Exp Pharmacal Physiol，2015，42（8）：828-836．