|
|
|
| Clinical effect of Insulin pump as an intensive therapy in patients with type 2 diabetes mellitus and its influence on blood glucose fluctuation |
| WEI Shu-xiang FANG Yong-hong LU Jie-can |
| Department of Endocrinology,Tongjiang Hospital of Foshan City in Guangdong Province,Foshan 528300,China |
|
|
|
|
Abstract ObjectiveTo comprehensively analyze the clinical effect of intensive Insulin pump therapy in patients with type 2 diabetes mellitus and its influence on blood glucose fluctuation.MethodsA total of 80 patients with type 2 diabetes treated in our hospital from July 2015 to July 2017 were selected as the subjects,and randomly divided into experimental group(short-term intensive Insulin pump therapy)and control group(routine subcutaneous injection of Insulin),40 cases in each group.The standard deviation of blood glucose before and after treatment,the average range of blood glucose fluctuation,the glycosylated hemoglobin,Insulin resistance index,the time of blood glucose reaching the standard,and the dose of Insulin on reaching the standard were analyzed.ResultsBefore treatment,the standard deviation of blood glucose and average blood glucose fluctuation in the two groups were not statistically significant(P>0.05).After therapy,the standard deviation and the average range of blood glucose fluctuation were significantly lower in the experimental group than that in the control group,the difference was statistically significant(P<0.05).In the experimental group,the time of blood glucose reaching the standard was significantly shorter compared with that in the control group,the difference was statistically significant(P<0.05).The Insulin dose in the experimental group was significantly less than that in the control group,the difference was statistically significant (P<0.05).The glycosylated hemoglobin and Insulin resistance index in the experimental group were greatly lower in comparison of those in the control group,the difference was statistically significant(P<0.05).ConclusionThe clinical effect of intensive Insulin pump therapy in patients with type 2 diabetes mellitus is remarkable.
|
|
|
|
|
|
| [1] |
林郁然.短期胰岛素强化治疗对2型糖尿病患者血糖控制效果的影响[J].中国急救医学，2016，36（z1）：157-158.
|
| [2] |
叶帅，陈明卫，胡红琳，等.34例持续6年胰岛素强化治疗的2型糖尿病患者随访观察[J].中华内分泌代谢杂志，2012，28（4）：293-294.
|
| [3] |
张朝巍，王春胜，韩俊起，等.甘精胰岛素强化治疗对2型糖尿病患者胰岛功能的影响[J].山东医药，2014，54（9）：103-104.
|
| [4] |
杨明明，程霖，许冰，等.短期胰岛素强化治疗对2型糖尿病患者外周血MCP-1和NF-κB表达的影响[J].海南医学，2017，28（2）：242-245.
|
| [5] |
Ramani K，Sekaran G.Production of lipase from Pseudomonas gessardii using blood tissue lipid and thereof for the hydrolysis of blood cholesterol and triglycerides and lysis of red blood cells[J].Bioprocess Biosyst Eng，2012，35（6）：885-896.
|
| [6] |
戴尧，陈明卫，张超学，等.持续6年胰岛素强化治疗对2型糖尿病患者血清炎症因子及颈动脉内-中膜厚度影响的观察[J].中国糖尿病杂志，2014，22（5）：417-419.
|
| [7] |
Arvelos S，Rade L，Watanabe EO，et al.Evaluation of different contribution methods over the performance of Peng-Robinson and CPA equation of state in the correlation of VLE of triglycerides，fatty esters and glycerol+CO2and alcohol[J].Fluid Phase Equilibria，2014，362：136-146.
|
| [8] |
邓学军，魏淑芬，谷小云，等.短期胰岛素强化治疗对2型糖尿病患者血糖、血脂及胰岛功能的影响[J].河北医药，2016，38（13）：1937-1939.
|
| [9] |
张林波，李兴，庞紫蕊，等.胰岛素强化治疗对2型糖尿病患者血清脂联素水平的影响[J].中国现代药物应用，2015，15（21）：273-276.
|
| [10] |
张丹乔，戚以勤，冯琬婷，等.2型糖尿病视网膜病变与下肢血管病变的关系[J].中山大学学报（医学科学版），2017，38（5）：732-737.
|
| [11] |
黄镇河，吕术昕，黎丽萍，等.胰岛素强化治疗对2型糖尿病患者静息能量消耗的影响[J].中国糖尿病杂志，2011，19（3）：207-209.
|
| [12] |
高文颖.短期胰岛素强化治疗对2型糖尿病患者胰岛β细胞功能的影响分析[J].基层医学论坛，2016，20（10）：1330-1331.
|
| [13] |
孙习军，田志英，周洁.胰岛素泵与口服降糖药治疗对糖尿病病人颈动脉粥样硬化的影响[J].中西医结合心脑血管病杂志，2017，15（18）：2307-2309.
|
| [14] |
钱秦娟，董宏，费志永，等.胰岛素强化治疗对2型糖尿病患者静息能量消耗的影响研究[J].中国医刊，2017，52（4）：101-105.
|
| [15] |
Wu C，Liu X，Li Y，et al.Lipase-nanoporous gold biocomposite modified electrode for reliable detection of triglycerides[J].Biosens Bioelectron，2014，15（53）：26-30.
|
|
|
|
