还原型谷胱甘肽联合消炎止痛药物合剂在急性放射性食管炎中的应用研究

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Abstract ObjectiveTo observe effect of reduced glutathione combined with anti-inflammatory analgesic mixture in the prevention and treatment of acute radiation esophagitis during the radiotherapy for esophageal carcinoma.Methods72 cases of esophageal carcinoma patientswith thoracic radiotherapy in the First Affiliated Hospital of Henan University of Science and Technology from May 2014 to November 2015 were randomly divided into experimental group and control group.Patients in the experimental group group received reduced glutathione combined with anti-inflammatory analgesic mixture during radiotherapy,while patients in the control group received anti-inflammatory alone.The incidence of actue radiation esophagitis,tolerance dose of esophagealmucosal and the proportion of patients for whom antibiotics were used in two groups were experimentald and evaluated.Results72 patients all completed the treatment course.The incidence of gradeⅡor above actue radiation esophagitiswas 100.0%in two groups,The incidence of grade Ⅱor above actue radiation esophagitis in the experimental group and the control group was 33.3%and 63.9%respectively,and the difference was statistically significant(χ2=6.727,P<0.01),there were no gradeⅣacute esophagealmucosal injury in the two group.The tolerance dose of esophagealmucosa in the experimental group was higher than that in the control group (P<0.01).Use proportionof antibiotics in the treatment of radiation esophagitis in the experimental group was 13.9%,with 44.4%in the control group,and the difference was statistically significant(χ2=8.314,P=0.004).ConclusionReduced glutathione has a good effect on the prevention and treatment of acute esophagealmucosal injury in patientswith esophageal carcinoma.It can reduce the incidence and severity of acute radiation esophagitis.

Key words： Esophageal carcinoma Reduced glutathione Radiotherapy Acute radiation esophagitis

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	Articles by authors
	LIJing-xia
	MU Shuang-feng
	WANG Xiao-hong
	MU Li-xiang

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LIJing-xia,MU Shuang-feng,WANG Xiao-hong, et al. Application research of reduced glutathione combined with antiinflammatory analgesic mixture in the treatment of acute radiation esophagitis[J]. 中国当代医药, 2016, 23(33): 31-33.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I33/31

[1]	刘江，任伟，刘宝瑞，等.放射性食管炎相关预测因素及防治的研究进展[J].现代肿瘤医学，2014，22（7）：1690-1693.
[2]	马春曦，邓兰，彭国林，等.谷氨酰胺治疗急性放射性食管炎的疗效[J].南昌大学学报（医学版），2015，55（2）：80-82.
[3]	殷蔚伯，余子豪，徐国镇，等.肿瘤放射治疗学[M].4版.北京：中国协和医科大学出版社，2008：1350.
[4]	郭金，史恒军.蛋珍油治疗放射性食管炎60例临床观察[J].现代肿瘤医学，2016，24（13）：2085-2087.
[5]	武治明.中西医结合治疗40例放射性食管炎的临床研究[J].甘肃医药，2014，33（4）：265-267.
[6]	严小杰，和光宇.芬太尼贴剂治疗放射性食管炎所致疼痛的临床观察[J].现代肿瘤医学，2015，23（10）：1374-1376.
[7]	陈新谦，金有豫，汤光.新编药物学[M].17版.北京：人民卫生出版社，2011：885.
[8]	袁平戈，张大志.还原型谷胱甘肽的作用机制及临床应用[J].药品评价，2006，3（5）：385-390.
[9]	Zendehdel N，Biramijamal F，Zendehdel N，et al.The role and frequency of glutathione s-transferase P1 polymorphism in Iranian patients affected with reflux esophagitis[J].Dis Esophagus，2010，23（7）：603-607.
[10]	高莹，陈河润，朱向高，等.口服爱维治治疗急性放射性食管炎的病理研究[J].重庆医学，2014，43（21）：2759-2761.
[11]	黄辉，樊晓静.扶正减毒颗粒防治急性放射性食管炎的临床观察[J].现代肿瘤医学，2015，23（13）：1849-1852.
[12]	章艳，崔鸣欧.重组人白介素-11含服液防治食管癌患者放射性食管炎的效果观察[J].护理学报，2014，21（24）：46-48.
[13]	张燕玲，周焱，张雪梅.还原性谷胱甘肽对肺癌放射治疗患者的保护作用[J].实用老年医学，2001，15（2）：91-92.
[14]	郭秀丽，姚士伟，张峻，等.异甘草酸镁联合还原型谷胱甘肽治疗化疗药物性肝损伤临床疗效观察[J].实用肝脏病杂志，2014，17（6）：575-578.
[15]	雷章，卢宏达，卢驰，等.还原型谷胱甘肽对大鼠急性放射性肺损伤炎症的影响[J].中国医院药学杂志，2014，34 （17）：1449-1453.