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| Effect of Zhike Pingchuan Decoction on children with bronchial asthma and its influence on sub-group of T lymphocyte and serum of IL-4 and IFN-γ |
| LIU Yuan-song |
| Maternal and Child Health Hospital in Luojiang District of Quanzhou City,Fujian Province,Quanzhou 362000,China |
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Abstract ObjectiveTo explore the effect of Zhike Pingchuan Decoction on children with bronchial asthma and its influence on sub-group of T lymphocyte and serum of interferon-γ(IFN-γ)and interleukin-4(IL-4).MethodsA total of 82 children definitely diagnosed as bronchial asthma in our hospital from June 2012 to April 2016 were selected as research objects.They were randomly divided into control group(n=40)and observation group(n=42).In the control group, inhalant of Budesonide Formoterol Powder was used,while in the observation group,Zhike Pingchuan Decoction was added on the basis of the control group.The course of treatment was 3 months.The clinical effect in the two groups was compared.ResultsAfter 3-month therapy,frequency of asthma attack per month and frequency of upper respiratory infection (URI)were both less than those before treatment,the time of asthma after treatment was shorter,the IL-4 level was lower and the INF-γ level was higher in comparison with those before treatment,the differences were statistically significant(P＜0.05).In the observation group,frequencies of asthma attack per month and URI were less than those in the control group after 3-month therapy,symptom of asthma was shorter,the level of IL-4 was lower and level of INF-γ was higher than those in the control group after therapy,the differences were statistically significant(P＜0.05).In the control group,sub-group of T lymphocytes incuding CD3+,CD4+,and CD4+/CD8+was not greatly improved,while in the observation group,these indexes were significantly improved,the differences were statistically significant(P＜0.05).The total effective rate in the observation group was 92.86%,much higher than that in the control group(77.50%),the difference was statistically significant(P＜0.05).ConclusionApplication of Zhike Pingchuan Decoction is effective in treating bronchial asthma,which can improve the inflammatory response and immune function,and is worthy of promotion.
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