第四脑室形成菊形团的胶质神经元肿瘤临床病理观察

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Abstract ObjectiveTo explore clinical pathological characteristics,imaging changes and differential diagnosis of rosette-forming glioneuronal tumor (RGNT)in the fourth ventricle for improving the understanding of the disease.MethodsThe clinical,radiological,and pathological features of the three patients with RGNT in our hospital from November 2007 to July 2015 were analyzed retrospectively,and the relevant literature were reviewed.ResultsAll the patients were male with a mean age of 19 years(from 14 to 26).The clinical symptoms included dizziness,vomiting,ataxia and so on.MRI revealed hypo-intensity on T1-weighted image,hyper-intensity on T2-weighted image.Histopathological findings showed the typical biphasic feature with neurocytic and glial architecture.The neoplastic tissue consisted of small cells with round nuclei resembling neurocytes often arranged to form neurocytic rosettes or perivascular rosettes radiating around central capillaries.The glial component tended to exhibit pilocytic astrocytoma like morphology with long,hair-like processes.ConclusionRGNT in the fourth ventricle is a rare and slow growth neoplasm.The tumor often occur in the fourth ventricle,with its unique histological,immunohistochemical features.Current management has relied on surgery,and postoperative long-term close follow-up is needed.

Key words： Ventricle tumor Glioneuronal tumor The fourth ventricle Rosette-forming Pathological feature

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	Articles by authors
	LI Yun-yuan
	LI Wei-qing
	MA Xiao-mei
	XU Rong-rong
	XIA Chun-yan

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LI Yun-yuan,LI Wei-qing,MA Xiao-mei, et al. Clinical and pathological observation on the rosette-forming glioneuronal tumor of the fourth ventricle[J]. 中国当代医药, 2016, 23(36): 11-14.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I36/11

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