妊娠期肝内胆汁淤积症不良母婴结局的临床分析

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Abstract Objective To explore the effect of intrahepatic cholestasis of pregnancy (ICP)on maternal and neonatal outcomes.Methods 65 patients with ICP from January 2008 to December 2015 treated in our hospital were selected as study group,and they were divided into mild group (43 cases)and severe group (22 cases)according to the level of serum total bile acid;71 healthy parturient from our hospital at the same period were selected as control group.The difference of maternal and infant outcome between two groups were observed.Results Incidence of premature,meconium stained amniotic fluid,cesarean section and postpartum hemorrhage in study group was obvious higher than that in the control group respectively,the difference was statistically significant(P＜0.05);the incidence of premature rupture of membranes in the two groups had no significant difference(P＞0.05);the incidence of low birth weight infants,fetal distress and neonatal asphyxia of the study group was compared with the control group,and the difference was statistically significant(P＜0.05).Incidence of premature,meconium stained amniotic fluid,low birth weight infants,fetal distress and neonatal asphyxia in severe group was higher than that in mild group respectively(P＜0.05),the incidence of premature rupture of membranes,cesarean section,and postpartum hemorrhage had no significant difference between two groups (P＞0.05).Conclusion Intrahepatic cholestasis of pregnancy is an important cause of adverse maternal and neonatal outcomes,nursing staff should strengthen prenatal care for maternal and perinatal fetal care.Early detection,prevention and treatment should be done for intrahepatic cholestasis of pregnancy.

Key words： Intrahepatic cholestasis of pregnancy Total bile acid Perinatal infant Maternal and neonatal outcomes

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	PAN Fang-li
	LIANG Quan-fang
	ZHOU Yin-yan

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PAN Fang-li,LIANG Quan-fang,ZHOU Yin-yan. Clinical analysis of adverse effect of intrahepatic cholestasis of pregnancy on maternal and neonatal outcomes[J]. 中国当代医药, 2017, 24(5): 61-63.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I5/61

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