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| Effectiveness and safety study of initiating basal insulin therapy in type 2 diabetes mellitus |
| XU Ding-bo |
| Department of Endocrinology and Metabolism,the Third Hospital of Nanchang City in Jiangxi Province,Nanchang 330009,China |
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Abstract Objective To explore the efficacy and safety of basal insulin therapy in combiantion in type 2 diabetes mellitus patients who took hypoglycemic agents orally and didn′t obtain a favorable effect.Methods From January 2013 to June 2015,100 patients with T2DM from outpatient clinics and inpatient departments in unsatisfied effect when oral administration of hypoglycemic agents in our hospital were selected and they were asked to add basal insulin therapy besides oral administration of hypoglycemic agents.According to different types of basal insulin,they were divided into neutral protamine hagedorn(NPH)insulin group(n=33),insulin glargine group(n=34)and insulin detemir group(n=33). The indexes of FPG,2 h PG,HbA1c,BMI,occurrence of hypoglycemia,and quality of life among three groups before and after therapy were compared.Results After treatment,the levels of FPG,2 h PG and HbA1c were significantly decreased than before treatment(P＜0.01).The BMI in the NPH insulin group was increased compared with that before treatment (P＜0.05),while BMI in the insulin glargine group and insulin detemir group were compared before treatment,with no statisticant difference (P＞0.05).Compared with the NPH insulin group,occurrence of hypoglycemia in the insulin glargine group and insulin detemir group was much lower (P＜0.05).The scores of EQ-5D after therapy in the three groups were remarkably increased compared with those before treatment(P＜0.05).Conclusion For T2DM patients who take hypoglycemic agents orally without a great effect,initiation of basal insulin in time is safe and effective,which is better by long-acting insulin analogues in effectiveness and safety.
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