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| Analysis on the effect of BiPAP intermittent ventilation combined with Naloxone in the treatment of acute exacerbation of chronic obstructive pulmonary disease complicated with respiratory failure |
| LIN Nong-wei |
| Department of Respiratory Medicine,Xinhui People′s Hospital of Jiangmen City in Guangdong Province,Jiangmen 529100, China |
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Abstract Objective To investigate the effect of BiPAP intermittent ventilation combined with Naloxone in the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD)complicated with respiratory failure. Methods 46 patients with AECOPD complicated with respiratory failure who were hospitalized in our hospital from January 2012 to December 2014 were selected and randomly divided into the BiPAP ventilation group and the control group,23 cases in each group.The control group was given conventional oxygen therapy,anti-infection,antispasmodic,and symptomatic treatment,if necessary,the control group was given mechanical ventilation treatment.The BiPAP ventilation group was treated with intermittent ventilation by BiPAP non-invasive ventilator combined with Naloxone on the basis of the conventional oxygen therapy,anti-infection,antispasmodic,and symptomatic treatment.Changes in arterial blood gas analysis and changes in 6-minute walking distance before and after treatment were observed between the two groups.Results The level of PaO2in the two groups after treatment was higher than that before treatment,and the level of PaCO2in the two groups after treatment was lower than that before treatment,with significant difference(P＜0.05).The level of PaO2in the BiPAP ventilation group after treatment was higher than that in the control group,and the level of PaCO2in the BiPAP ventilation group after treatment was lower than that in the control group,with significant difference (P＜0.05).6-minute walking distance after treatment in the two groups was longer than that before treatment,with significant difference(P＜0.05).6-minute walking distance in the BiPAP ventilation group after treatment was longer than that in the control group,with significant difference (P＜0.05).There was no need for endotracheal intubation and mechanical ventilation in the BiPAP ventilation group.Conclusion BiPAP intermittent ventilation combined with Naloxone is effective in the treatment of patients with AECOPD complicated with respiratory failure and has no adverse reactions.
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| [1] |
林涛，邹文英，邓治平，等.无创呼吸机联合纳洛酮治疗COPD并发呼吸衰竭的疗效观察[J].现代诊断与治疗，2012，23（4）：263-264.
|
| [2] |
陈天铎，董晨明，李培杰，等.纳络酮对心肺脑复苏作用的评价[J].急诊医学，2000，9（1）：5-7.
|
| [3] |
季蓉，何权瀛.内源性阿片肽在呼吸调控中的作用[J].中华结核和呼吸感染，1999，22（7）：440.
|
| [4] |
中华医学会呼吸病学分会慢性阻塞性肺疾病学组.慢性阻塞性肺疾病诊治指南（2007年修订版）[J].中华结核和呼吸杂志，2007，30（1）：8-17.
|
| [5] |
徐圣葆.慢性阻塞性肺疾病并发呼吸衰竭相关危险因素分析[J].中国医师进修杂志2010，33（10）：4-6.
|
| [6] |
夏一碧.雾化吸入联合无创正压通气治疗COPD合并Ⅱ型呼吸衰竭的临床研究[J].中国当代医药，2013，20（29）：154-155.
|
| [7] |
龙苹，廖燕玲，易容松，等.压力调节容量控制通气治疗婴幼儿呼吸衰竭的疗效分析[J].广西医学，2009，31（6）：807-809.
|
| [8] |
刘旭春，陈浩，朱文忠，等.BiPAP呼吸机治疗老年COPD合并Ⅱ型呼吸衰竭的疗效分析[J].临床肺科杂志，2011，16（12）：1893-1894.
|
| [9] |
王辰.早期应用无创正压通气治疗慢性阻塞性肺疾病急性加重期患者的多中心随机对照研究[J].中华结核和呼吸杂志，2005，28（10）：680-684.
|
| [10] |
俞秋荔，范泽潮.纳洛酮联合川芎嗪治疗肺源性心脏病并呼吸衰竭的疗效观察[J].中国当代医药，2013，20（4）：73-74.
|
| [11] |
李海泉，赵杰，王海清，等.BiPAP联合振动排痰治疗AECOPD合并呼吸衰竭的效果评价[J].中国当代医药，2014，21（16）：30-31，34.
|
| [12] |
刘琰.Cpap与Bipap应用于急性左心衰合并呼吸衰竭患者的疗效研究[J].临床和实验医学杂志，2014，13（7）：552-554.
|
| [13] |
骆玲.BiPAP在合并Ⅱ型呼吸衰竭的COPD患者中的应用效果[J].实用临床医药杂志，2016，20（17）：35-37.
|
| [14] |
The American Thoracic Society，the European Respiratory Society，the European Society of Intensive Care Medicine et al.International consensus conferences in intensive care medicine：noninvasive positive pressure ventilation in acute respiratory failure[J].Am J Respir Crit Care Med，2001，163（1）：283-291.
|
| [15] |
玛依拉·阿不都克里木，库尔班江·吐尔逊，金小越，等. BiPAP呼吸机无创治疗COPD呼吸衰竭的临床观察（附50例病例分析）[J].现代预防医学，2013，40（12）：2375-2376，封3.
|
|
|
|
