美沙拉嗪口服联合结肠水疗、锡类散灌肠治疗溃疡性结肠炎患者的效果

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Abstract ObjectiveTo explore the clinical effect and influence on serum inflammatory factors of mesalazine orally combined with colonic hydrotherapy and Xilei Powder enema on patients withulcerative colitis(UC).Methods116 UC patients diagnosed and treated in our hospital from January 2015 to January 2017 were randomly divided into control group and observation group,with 58 cases in each group.The control group was treated with Mesalazine orally,and the observation group was treated with colon hydrotherapy and Xilei Powder enema on the basis of the control group.The clinical effect,serum levels of inflammatory factors and the incidence of adverse reactions were compared between the two groups.ResultsAfter 8 weeks of treatment,the total effective rate of the observation group was significantly higher than that of the control group (P＜0.05).The effective rate of the observation group was significantly higher than that of the control group(P＜0.05).The serum hs-CRP,TNF-α,IL-4,IL-8 and IL-10 levels of the two groups before treatment had no significant difference(P＞0.05).After 8 weeks of treatment,the serum levels of hs-CRP,TNF-α and IL-8 in the two groups were significantly lower than those before treatment(P＜0.05).The serum levels of IL-4 and IL-10 in the two groups were significantly higher than those before treatment(P＜0.05).The serum levels of hs-CRP,TNF-α and IL-8 in the observation group were significantly lower than those in the control group(P＜0.05),and the serum levels of IL-4 and IL-10 in the observation group were significantly higher than those in the control group (P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＜0.05).ConclusionMesalazine orally combined with colon hydrotherapy and Xilei Powder enema in the treatment of UC is better than Mesalazine simple drug treatment.It can significantly inhibit the inflammatory response,and the side effects are similar.

Key words： Mesalazine Xilei Powder Ulcerative colitis Serum inflammatory factors

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HE Xiao-rui. Effect of Mesalazine orally combined with colonic hydrotherapy and Xilei Powder enema on patients with ulcerative colitis[J]. 中国当代医药, 2018, 25(6): 46-49.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I6/46

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