血栓抽吸联合冠脉内给予尼可地尔对急性心肌梗死急诊PCI术后无复流的影响

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Abstract Objective To investigate the effect and security of thrombus aspiration associated with Nicorandil in coronary on no-reflow of acute myocardial infarction after emergency percutaneous coronary intervention(PCI).Methods 120 patients in our hospital from December 2014 to December 2015,with emergency PCI for ST elevation myocardial infarction,preoperative infarction related artery(IRA)thrombolysis in myocardial infarction(TIMI)≤grade 1,were randomly divided into nicorandil group and control group according to the medical record number,each group had 60 patients.Two group did the same operation.When no-reflow after PCI appeared,intracoronary Nicorandil or Nitroglycerin was administered in each group separately.At the end of PCI,TIMI grade and TIMI myocardial perfusion grade(TMPG) were observed in the two groups,ST-segment down of ECG and the incidence of major adverse cardiac events(MACE)during hospitalization were compared between two groups.Results The proportion of with TIMI grade and TMPG grade of the nicorandil group was significantly better than that of the control group(P＜0.05).The incidence rate of ST-segment down of the nicorandil group was significantly higher than that of the control group(P＜0.05).The incidence rate of MACE in the nicorandil group was significantly lower than that in the control group before discharge(P＜0.05).Conclusion The therapy of thrombus aspiration associated with Nicorandil in coronary for no-reflow of acute myocardial infarction after emergency PCI can improve coronary blood flow and myocardial reperfusion in infarct area,improve shortterm prognosis and is safe and effective.

Key words： Acute myocardial infarction Percutaneous coronary intervention Thrombus aspiration Nicorandil

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	WU Jun
	DENG GEN-qun

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WU Jun,DENG GEN-qun. Effects of thrombus aspiration associated with Nicorandil in coronary on no-reflow of acute myocardial infarction after emergency PCI[J]. 中国当代医药, 2017, 24(7): 60-63.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I7/60

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