瑞舒伐他汀联合普罗布考抗动脉粥样硬化的临床观察

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Abstract Objective To obsreve the effect of Rosuvastatin combined with Probucol in the treatment of atherosclerosis. Methods 180 cases of coronary heart disease from January 2013 to June 2015 treated in our hospital were selected and randomly divided into the combination group,the Rosuvastatin group and the Probucola group,60 cases in each group. All of them were treated for 6 months.The combined group was treated with Rosuvastatin combined with Probucol Tablets,the Rosuvastatin group was only given Rosuvastatin,the Probucol group was only given Probucol.The effective rate of each group was measured,the levels of serum cholesterol,high density lipoprotein and low density lipoprotein were detected,and the intima-media thickness of carotid artery was calculated.The therapeutic effects of the three groups were evaluated.Results The total effective rate of the combined group was significantly higher than that of the Rosuvastatin group and the Rrobucol group,with significant difference(P＜0.05).There was no significant difference in total effective rate between the Rosuvastatin group and the Probucol group(P＞0.05).There was significant difference in the levels of total cholesterol,high-density lipoprotein,low-density lipoprotein and carotid intima-media thickness of thecombined group before and after treatment(P＜0.05).There was significant difference in the level of serum total cholesterol and high density lipoprotein cholesterol before and after treatment in the Rosuvastatin group(P＜0.05).There was significant difference in the level of low density lipoprotein and carotid intima media thickness in the Probucol group before and after treatment(P＜0.05).There was significant difference in the level of low density lipoprotein and carotid intima media thickness after treatment between the combined group and the Rosuvastatin group(P＜0.05).There was significant difference in the level of the total cholesterol,high density lipoprotein and carotid intima-media thickness after treatment between the combined group and the Probucol group(P＜0.05).There were significant differences in the level of total cholesterol,high density lipoprotein,low density lipoprotein and carotid intima media thickness after treatment between the Rosuvastatin group and the Probucol group(P＜0.05).Conclusion Rosuvastatin conbined with Probucol can effectively inhibit atherosclerosis,compared with a single drug,which can significantly improve the efficacy,it is worthy of promotion and application in clinical practice.

Key words： Rosuvastatin Probucol Coronary heart disease Clinical effect

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	Articles by authors
	ZOU Yan-ming
	YAO Yuan-ying
	LI Rong
	XIN Hui

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ZOU Yan-ming,YAO Yuan-ying,LI Rong, et al. Clinical observation of Rosuvastatin combined with Probucol in the treatment of atherosclerosis[J]. 中国当代医药, 2017, 24(10): 48-52.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I10/48

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