实时超声弹性成像技术在大鼠梗阻性黄疸模型定量诊断中的价值

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Abstract Objective To explore the quantitative diagnostic value of RTE for quantitative analysis of the elasticity of the liver changes in rats with obstructive jaundice.Methods 30 male SD rats(2.5-3.0 months,280-330 g)were randomly divided into group A(experimental group)and group B(control group),15 rats in each group.Rats of the group A was operated to make refolding obstructive jaundice animal model,while group B was only given the sham operation.Ultrasound diagnostic imaging software was used to analyze the elasticity of the liver changes of the animal models preoperative, 2 weeks after the modeling and 2 weeks after the removal of the obstruction;and the diffusion quantitative analysis of the elastic image,the percentage of blue areas(%AREA)and strain mean(MEAN)within the region of interest(ROI)of the rat liver were measured and recorded.The changes of%AREA and MEAN in the two groups were compared at preoperative,2 weeks after the modeling and 2 weeks after the removal of the obstruction.Results There was no significant difference in%AREA and MEAN between the two groups at preoperative and 2 weeks after obstruction relieving(P＞0.05).The AREA and MEAN of group A were 42.60±3.69,93.20±2.54,compared with the group B of 25.40±1.40,108.00± 4.93,the difference was statistically significant(t=6.230,P=0.019;t=4.328,P=0.047).The AREA and MEAN values at 2 weeks after modeling were compared with those at preoperative and 2 weeks after obstruction relieving,the differences were statistically significant(P＜0.05).Conclusion Diffusion quantitative analysis of RTE can reflect the liver changes caused by obstructive jaundice,the MEAN and%AREA in the ROI of the liver after obstructive jaundice may change significantly,which can be used as quantitative indicators of the degree of obstructive jaundice reference.

Key words： RTE;Obstructive jaundice;MEAN value %AREA

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	MENG Ye
	XIAO Yang
	LIU Yong
	WANG Tao
	XI Ke-min

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MENG Ye,XIAO Yang,LIU Yong, et al. Quantitative diagnostic value of real-time ultrasound elastography in rats with obstructive jaundice[J]. 中国当代医药, 2017, 24(10): 8-11.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I10/8

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