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| Study of efficacy and safety of Clopidogrel combined with Atorvastatin and Low Molecular Dextran in the treatment of cerebral watershed infarction |
| LUO Wen-feng LIU Jun-jie LAI Hai-yan LUO Ting |
| Department of Neurology,People′s Hospital of Huichang County,Jiangxi Province,Ganzhou 342600,China |
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Abstract Objective To investigate the efficacy and safety of Clopidogrel combined with Atorvastatin and Low Molecular Dextran in the treatment of cerebral watershed infarction.Methods From October 2016 to January 2017,the clinical data of 65 patients with cerebral watershed infarction in our department were analyzed.According to different therapeutic methods,they were divided into the control group (n=25) and the observation group (n=40).The control group was treated with low molecular dextran,and the observation groupwas treated with Clopidogrel combined with Atorvastatin.The activities of daily living (ADL) score,NIHSS score,and BI score before and after treatment were compared between the two groups.The total effectiveness rate of clinical treatment,the incidence rate of deterioration of neurological function in the 7 days of cerebral watershed infarction,symptomatic intracranial hemorrhage,and death were observed in the two groups.Results There was no significant difference in the ADL score,NIHSS score,and BI score before treatment in the two groups (P＞0.05).The ADL score,NIHSS score,and BI score after treatment in the two groups were all higher than those before treatment,and the ADL score,NIHSS score,and BI score after treatment in the observation group were all superior to those in the control group,with significant difference (P＜0.05).The total effectiveness rate in the observation group was higher than that in the control group,the incidence rate of neurological deterioration in the 7 days of cerebral watershed infarction,symptomatic intracranial hemorrhage,and death in the observation group were lower than those in the control group,with statistical differences (P＜0.05).Conclusion Application of Clopidogrel combined with Atorvastatin in the treatment of cerebral watershed infarction has a remarkable clinical effect,great improvement of clinical symptoms,and low incidence of adverse events,which is worthy of clinical promotion and application.
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