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| Clinical effect and safety of Zoledronic Acid Injection combined with Caltrate D in treatment of diabetic osteoporosis |
| HUANG Bing |
| Department of Endocrinology,Shenzhen People′s Hospital,Guangdong Province，Shenzhen 518000,China |
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Abstract ObjectiveTo probe into the clinical effects and safety of Zoledronic Acid Injection combined with Caltrate D in treatment of diabetic osteoporosis.Methods77 cases of patients with diabetic osteoporosis and who accepted treatments in our hospital from April 2012 to April 2016 were selected as the research object，and were grouped by the random number table method,the observation group of 39 cases and the control group of 38 cases.The control group were used the conventional hypoglycemic therapy combined with Caltrate D treatment,while the observation group was added with Zoledronic Acid Injection on the basis of the control group.Then,the changes of bone mineral density,bone metabolism and adverse reactions after treatment of two groups of patients were observed.ResultsBefore treatment,there was no significant difference in bone mineral density of the femoral neck,lumbar spine and Ward′s triangle between the two groups（P＞0.05）,after the treatment,the bone mineral density levels of two groups of patients were improved,and the bone mineral density after treatment in the observation group was significantly higher than that of the control group,the difference was statistically significant（P＜0.05）.Before the treatment,there was no significant difference in the ALP,Ca,P,HCT,BGP and other bone metabolic markers between two groups of patients（P＞0.05）,after the treatment,the ALP in the control group was lower than that before treatment,and there was no significant difference between the other indexes（P＞0.05）,and the changes of the indexes in the observation group were statistically significant compared with the control group （P＜0.05）.There was no serious adverse reactions of two groups of patients，the observation group had 2 cases of nausea,bone pain,fever and other symptoms,disappeared after symptomatic treatment.ConclusionThe Zoledronic acid combined with Caltrate D which can improve bone mineral density in patients with diabetic osteoporosis,improve bone metabolism,and safety is high,thus it is worthy to be promoted.
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