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Analgesic effect of Sufentanil combined with Remifentanil on esophageal cancer surgery and its effect on stress response |
ZHANG Bo-qing YANG Li XIAO qing-hua QIU Wei-dong |
Department of Anesthesiology,First People′s Hospital of Shaoguan,Guangdong Province,Shaoguan 512000,China |
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Abstract ObjectiveTo investigate the analgesic effect of Sufentanil combined with Remifentanil in esophageal cancer surgery and its effect on stress response.Methods90 patients with esophageal cancer surgery from January 2015 to December 2016,were selected and divided into 3 groups,30 patients were given Sufentanil anesthesia induction(study group 1),30 patients were given Remifentanil anesthesia induction(study group 2),30 patients were given Sufentanil and Remifentanil anesthesia (study group 3).HR,SBP,DBP,NE,E,Cor and VAS score,extubation time,cases of postoperative analgesic requirements in different time of the three groups were compared.ResultsHR,SBP and DBP of the three groups in T2were significantly decreased compared with T1(P<0.05).HR,SBP and DBP in T3,T5and T7in study group 2 were significantly higher than those in the other two groups(P<0.05).The plasma NE concentration in T4,T6and T8of study group 2 was significantly higher than that of the other two groups(P<0.05).The postoperative extubation time of study group 2 and 3 was significantly shorter than that of study group 1(P<0.05).There were significant differences in the VAS score and the ratio of patients who required analgesia between the study group 2 and the other two groups (P<0.05).ConclusionSelection of Sufentanil and Remifentanil has good analgesic effect of anesthesia in patients with esophageal cancer surgery,and stress response is little,hemodynamic stability is high,extubation time is short.
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