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| Efficacy of age and menstrual cycles on human serum HE4 and CA125 levels |
| LIU Yuan-ling1 HUANG Xiao-fen1 NIE Shi-chan2 CHEN Cai-xiang1 HUANG Ping1 |
1.Department of Gynecology and Obstetrics,Songgang People′s Hospital of Baoan District in Guangdong Province,Shenzhen 518105,China;
2.Department of Laboratory,Songgang People′s Hospital of Baoan District in Guangdong Province, Shenzhen 518105,China |
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Abstract ObjectiveTo investigate the effects of age and menstrual cycle in human serum carbohydrate antigen 125 (CA125)and the human epididymis protein 4(HE4).Methods160 healthy women checked physical examination center in our hospital from January 2015 to August 2015 were divided into premenopause group(114 cases)and control group (46 cases),the premenopause group was divided into two groups,age≤35 years old(61 cases)and age＞35 years old(53 cases). Serum CA125 and HE4 levels at different stages during menstrul cycle of the groups were compared,serum CA125 and HE4 levels of the groups≤35 years old and＞35 years old at different stages during menstrul cycle were compared.ResultsThere was no statistically significant difference in serum CA125 level of the premenopause group at different stages during the menstrual cycle(P＞0.05),and there was statistically significant difference in serum HE4 level(P＜0.05), compared the luteal phase with the follicular phase,there was not statistically significant difference(P＞0.05),the follicular phase and the luteal phase were lower than those of the ovulation phase,the differences were statistically significant (P＜0.05);the serum HE4 level in the ovulation phase of the women of the group≤35 years old were higher than that of the women in the follicular phase and the luteal phase(P＜0.05),and there were no statistically significant difference in serum HE4 level at various stages during the menstrual cycle of the group＞35 years old at various stages during the menstrual cycle(P＞0.05).There were no statistically significant differences in serum CA125 level at various stages during the menstrual cycle of the group≤35 years old and the group＞35 years old at various stages during the menstrual cycle.The serum CA125 and HE4 levels in the menopause were higher than those at various stages during the menstrual cycle of the premenopause(P＜0.05),the difference was statistically significant.ConclusionThe serum HE4 level of healthy women is affected by the menstrual cycle and age,the serum CA125 level is influenced by age,the clinical definition of HE4 and CA125 in diagnosis of threshold should be considered these factors.
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