腹腔镜手术治疗重症急性胰腺炎的临床效果及对患者免疫功能的影响

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Abstract Objective To observe the clinical effect of laparoscopic surgery in treatment of severe acute pancreatitis (SAP) and its influence on immune function.Methods 60 SAP patients treated in our hospital from August 2016 to July 2017 were selected,and divided into control group and observation group by random number table,30 cases in each group.The control group was given open surgery,while observation group was given laparoscopic surgery.The levels of cytokines,inflammatory indexes and changes of immune function in two groups before and after treatment were observed.Results Before treatment,there was no statistical difference in the levels of matrix metalloproteinase 9 (MMP-9),intercellular adhesion molecule-1 (ICAM-1),high mobility group box-1 protein (HMGB1),interleukin-6 (IL-6),high-sensitivity C-reactive protein (hs-CRP), procalcitonin (PCT),CD8+, CD4+, CD3+between the two groups (P>0.05).After treatment,the levels of ICAM-1,CD8+,IL-6,hs-CRP,PCT in observation group [(231.34±24.50) ng/ml,(24.13±1.95)%,(18.92±2.16) pg/ml,(8.24±1.07) mg/L,(5.11±0.40)μg/L] were lower than those in the control group,while the levels of CD4+ and CD3+ in observation group [(37.14±1.82)%,(78.92±3.46)%] were higher than those in the control group (P<0.05).Conclusion Laparoscopic surgery in treatment of SAP is effective,which can promote recovery of immune function and cure disease,improve physical-mental state and living quality of patients.

Key words： Severe acute pancreatitis Open surgery Laparoscopic surgery Cytokine Immune function

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	PENG Jian-cheng XU Xiao-dong PENG Lei LI Qiu PENG Quan-sheng PENG Yuan-lan LIU Qian

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PENG Jian-cheng XU Xiao-dong PENG Lei LI Qiu PENG Quan-sheng PENG Yuan-lan LIU Qian. Clinical effect of laparoscopic surgery in treatment of severe acute pancreatitis and its influence on immune function[J]. 中国当代医药, 2017, 24(36): 24-26.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I36/24

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