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| Clinical effect of Aripiprazole in the treatment of epileptic mental disorders |
| MA Chun-li XU Tian-ying |
| The First Department of Neurology,the Second Affiliated Hospital of Mudanjiang Medical College,Heilongjiang Province,Mudanjiang 157000,Chian |
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Abstract Objective To investigate the clinical effect of Aripiprazole in the treatment of epileptic mental disorders.Methods From January to December in 2018,60 epileptic patients with mental disorders were selected as the research objects,and divided into experimental group and control group according to the dice rolling method,each had 30 cases.The control group was treated with Perphenazine and the experimental group with Aripiprazole.The clinical efficacy,positive and negative symptoms scale (PANSS) score,mini-mental tate examination scale (MMSE) score,Hamilton Anxiety Scale (HAMA) score,Hamilton depression scale (HAMD) and quality of life score of the two groups were compared before and after treatment. Results The total effective rate of the experimental group was higher than that of the control group,the difference was statistically significant (P<0.05).There was no significant difference in PANSS between the two groups before treatment (P>0.05).After treatment,the scores of general psychopathology,positive symptoms,negative symptoms and total scores in the experimental group were lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,the scores of MMSE and quality of life in the experimental group were higher than those in the control group,and the scores of HAMA and HAMD were lower than those in the control group,the differences were statistically significant (P<0.05).Conclusion Aripiprazole is more effective in the treatment of mental disorders caused by epilepsy,and it can effectively improve the symptoms and signs of patients,improve the mental state and mental state of patients,and improve the quality of life of patients.
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| [1] |
张金铭.阿立哌唑治疗癫痫所致精神障碍的临床研究[J].中国卫生标准管理，2017，8（1）：67-68.
|
| [2] |
杨静，王平平，俞丹，等.中国抽动障碍患者西药治疗随机对照试验证据现状与趋势分析[J].中国药物应用与监测，2018，15（3）：181-185.
|
| [3] |
黄凯，韦恒祺，韦卢建.阿立哌唑治疗癫痫所致精神障碍的临床研究[J].中外医学研究，2016，14（11）：108-110.
|
| [4] |
陈春荣，李顺斌.苯巴比妥对小儿热性惊厥的治疗效果及复发惊厥的危险因素分析[J].中国妇幼保健，2019，34（13）：3009-3012.
|
| [5] |
ICD-10 精神与行为障碍分类[EB/OL].https://www.who.int/substance_abuse/terminology/icd_10/zh/.
|
| [6] |
周振东，李亚平，刘群会，等.卵圆孔未闭致精神异常1 例[J].中国介入心脏病学杂志，2018，26（12）：719-720.
|
| [7] |
Ohno Y.Astrocytic Kir4.1 potassium channels as a novel therapeutic target for epilepsy and mood disorders[J].Neural Regen Res，2018，13（4）：651-652.
|
| [8] |
Tayeb H，Khayat A，Milyani H，et al.Supernatural explanations of neurological and psychiatric disorders among health care professionals at an academic tertiary care hospital in Saudi Arabia[J].J Nerv Ment Dis，2018，206（8）：589-592.
|
| [9] |
王敏建，邱继红，蒋国庆.阿立哌唑联合舍曲林治疗青少年Tourette 氏障碍临床分析[J].中国药业，2019，28（23）：60-62.
|
| [10] |
苏明兵，赵霞，杨建华，等.阿立哌唑与喹硫平治疗老年精神分裂症对照研究[J].云南医药，2019，40（6）：532-534.
|
| [11] |
林森.氟西汀联合小剂量阿立哌唑治疗强迫症的临床分析[J].中国冶金工业医学杂志，2019，36（5）：574-575.
|
| [12] |
汤超华，徐国洪，黎润仪，等.阿立哌唑辅助奥氮平治疗阿尔茨海默病伴精神障碍疗效观察[J].实用中西医结合临床，2018，18（6）：50-51.
|
| [13] |
马世发，张雄，郭秀华，等.利培酮与阿立哌唑对阿尔茨海默病伴精神障碍患者糖脂代谢的影响[J].国际精神病学杂志，2017，44（6）：1021-1023.
|
| [14] |
孙菡，单建华，罗新.阿立哌唑与奥氮平联合治疗老年阿尔茨海默病伴精神障碍的临床研究[J].中西医结合心脑血管病杂志，2018，16（22）：3370-3372.
|
| [15] |
张艳，高咏莉.奎硫平与阿立哌唑对老年脑血管病所致精神障碍的疗效分析[J].黑龙江医药，2018，31（5）：1061-1062.
|
| [16] |
王邦雷，王邦路，王虎成.奥氮平联合阿立哌唑治疗老年阿尔茨海默病伴精神障碍疗效分析[J].临床心身疾病杂志，2018，24（5）：191-193.
|
|
|
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