849名医院放射工作人员肝肾功能状况调查

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Abstract Objective To analyze the liver and kidney function examination of radiation staff in some medical institutions in Fujian Province,and to explore the effect of low-dose ionized radiation on liver and kidney function of radiation staff.Methods The physical examination personnel in the Fujian Occupational Disease Prevention and Control Hospital in August 2017 to February 2018 were selected as the research subjects,and divided into the observation group(849 hospital radiation staff)and the control group(398 non radiation exposed health examination personnel of the same period)according to the occupational history.Blood samples were collected on an automatic biochemical analyzer to detect the liver and kidney functions of the two groups,and the results were compared.Results The levels of alanine aminotransferase(ALT),blood urea nitrogen(BUN)and creatinine(CR)in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).The level of glutamyl transpeptidase(GGT)in the two groups was not statistically significant(P>0.05).According to gender,the levels of ALT,GGT,BUN and CR in the observation group of male were higher than those in the same group of female,the differences were statistically significant(P<0.05).The observation group was divided into four groups according to the age,the GGT,BUN levels were compared among each age groups,with statistical differences(P<0.05).There was no statistically significant difference in GGT level between the age 41-<51 years group and the age ≥51 years group(P>0.05),while the other groups were compared in pairs,the differences were statistically significant(P<0.05).There was no statistically significant of BUN levels between the age 31-<41 years group and the age 41-<51 years group,and no statistically significant of BUN levels between the age 41-<51 years group and the age 41-<51 years group(P>0.05);while the other groups were compared in pairs,the differences were statistically significant(P<0.05);the ALT,CR levels were compared among each age groups,with no statistical differences(P>0.05).The observation group was divided into four groups according to the seniority period,the GGT,BUN,CR levels were compared among each age groups,with statistical differences(P<0.05);the GGT levels between the seniority period <11 years group with other three groups were compared,with statistical differences(P<0.05);the BUN levels between the seniority period <11 years group with the seniority period 21-<30 years group were compared,and the BUN levels between the seniority period <11 years group with the seniority period ≥30 years group were compared,with statistical differences(P<0.05);the CR levels between the seniority period <11 years group with the seniority period 11-<21 years group were compared,and the CR levels between the seniority period <11 years group with the seniority period ≥30 years group were compared,with statistical differences(P<0.05);while the other groups were compared in pairs,there were no statistically significant differences(P>0.05);and GGT,BUN levels gradually increase with age and seniority.The liver and kidney functions of different types of work were compared,the differences were statistically significant(P<0.05);the ALT and GGT levels of the interventional radiation group was higher than the other three groups,with statistical differences(P<0.05);the BUN levels of the radioactive diagnostic group was lower than the radiation group and the interventional radiation group,with statistical differences(P<0.05);the CR levels of the radioactive diagnostic group was lower than the other three groups,with statistical differences(P<0.05);while the other groups were compared in pairs,there were no statistically significant differences(P>0.05).Conclusion Long-term low-dose ionization radiation has a certain damage to the liver and kidney function of radiation workers.GGT and BUN levels increase with age and service with a cumulative effect.The radioactive staff should enhance the awareness of radiation protection,strengthen scientific protection measures,and reduce radioactive damage.

Key words： Radiation workers Liver and kidney function Alanine aminotransferase Glutamyl transpeptidase Urea nitrogen Creatinine

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	YE Shu-min
	LIU Li

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YE Shu-min,LIU Li. Investigation on liver and kidney function of 849 radiation workers in hospital[J]. 中国当代医药, 2021, 28(18): 168-172.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I18/168

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