盐酸羟考酮缓释片联合硫酸吗啡缓释片治疗中晚期癌症患者爆发痛的效果

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Abstract Objective To investigate the effect of Hydroxycodone Hydrochloride Sustained-release Tablets combined with Morphine Sulfate Sustained-release Tablets on pain outbreak in patients with advanced cancer. Methods A total of 104 patients with cancer pain in the People′s Hospital of Jining Beihu Provincial Tourism Resort from December 2015 to December 2018 were selected and use random lotteny to divided into control group(52 cases)and observation group(52 cases). The control group was treated with oral morphine sulfate sustained-release tablets, and the observation group was treated with oral Morphine Sulfate Sustained-release Tablets combined with Hydroxycodone hydrochloride Sustainedrelease Tablets. The pain relief rate, serum index, pain stability time, number of outbreaks of pain, quality of life score and incidence of adverse reactions were compared between the two groups after treatment. Results After treatment,there was no statistically significant difference in the pain relief rate between the two groups(P＞0.05).Serum tumor necrosis facctor-α (TNF-α), interleukin-6 (IL-6), substance P (SP) of observation group after treatment were lower than before treatment, 5-hydroxytryptamine (5-HT) and β-endorphin (β-EP) were higher than before treatment, the differences were statistically significant (P＜0.05); serum of observation group after treatment TNF-α, IL-6, SP were lower than the control group, 5-HT, β-EP were higher than the control group, the differences were statistically significant (P＜0.05).The number of burst pains in the observation group was less than that of the control group, and the pain stabilization time was shorter than that of the control group, the differences were statistically significant (P＜0.05). The quality of life score of the observation group after treatment was higher than that of the control group, and the difference was statistically significant (P＜0.05). The comparison of the total incidence of adverse reactions between the two groups was not statistically significant (P＞0.05). Conclusion Hydroxycodone Hydrochloride Sustained-release Tablets combined with Morphine Sulfate Sustained-release Tablets can effectively reduce the number of pain outbreaks in patients with cancer pain, significantly increase the pain relief rate and improve the quality of life of patients, and are relatively safe.

Key words： Cancer pain Hydroxycodone Hydrochloride Sustained-release Tablets Morphine Sulfate Sustained-release tablets Burst pain Pain stabilization time

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YAO Hui-jie. Effect of Hydroxycodone Hydrochloride Sustained-release Tablets combined with Morphine Sulfate Sustained-release Tablets on pain outbreak in patients with advanced cancer[J]. 中国当代医药, 2021, 28(28): 152-156.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I28/152

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