促甲状腺激素受体抗体在诊断毒性弥漫性甲状腺肿病中的应用价值

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Abstract Objective To investigate the application value of thyroid stimulating hormone receptor antibody (TRAb) in the diagnosis of Graves disease.Methods A total of 760 cases of patients with thyroid diseases in People′s Hospital of Yangdong District in Yangjiang City from October 2019 to October 2020 were selected retrospectively.According to the clinical symptoms and signs, medical history and auxiliary examination results, they were divided into four groups:newly diagnosed Graves disease group (n=300), primary hypothyroidism group (n=200), thyroid nodule group (n=150)and hyperthyroidism subacute thyroiditis group (n=110).In addition, 50 cases of healthy people in the same period were selected as healthy control group.The serum levels of TRAb, anti-thyroid peroxidase antibody (ATpo), thyroglobulin antibody (TGAb) and the positive situations of the newly diagnosed Graves disease group and the healthy control group were statistically analyzed.The serum levels of TRAb and the positive situation of the five groups were statistically analyzed.The ROC curve was used to evaluate the application value of TRAb in the diagnosis of Graves disease.Results The serum levels of TRAb, ATpo and TGAb and their positive rates in the newly diagnosed Graves disease group were higher than those in the healthy control group, the differences were statistically significant (P＜0.05).The serum TRAb level of the newly diagnosed Graves disease group was higher than that of the primary hypothyroidism group, thyroid nodule group and hyperthyroidism subacute thyroiditis group, the differences were statistically significant (P＜0.05).The TRAb positive rate of the newly diagnosed Graves disease group was higher than that of the primary hypothyroidism group, thyroid nodule group and hyperthyroidism subacute thyroiditis group, the differences were statistically significant(P＜0.05).The area under the ROC curve of TRAb was 0.973, the critical v alue of diagnosis was 22.5 IU/mL,the sensitivity and specificity were 96.0% and 91.1% respectively, the correct rate, positive predictive value and negative predictive value were 92.6%, 82.8% and 98.1% respectively.Conclusion The application value of TRAb is high in the diagnosis of Graves disease.

Key words： Graves disease Primary hypothyroidism Thyroid nodules Subacute thyroiditis in hyperthyroidism Thyroid stimulating hormone receptor antibody ROC curve

Received: 25 December 2020

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