氧嗪酸钾联合不同造模剂对小鼠高尿酸血症的尿酸值的影响

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Abstract Objective To explore the effect of potassium oxonate combined with different modeling agents on the uric acid value of mice with hyperuricemia(HUA),and provide reference for early prevention and treatment of HUA and drug screening.Methods HUA was modeled in ICR mice with 300 mg/kg potassium oxonate,500 mg/kg uric acid,500 mg/kg hypoxanthine and 250 mg/kg ethambutol.Blood samples were taken at different time periods to determine the uric acid value to compare the effects of different modeling factors on blood uric acid.Results The adminwastration of 300 mg/kg potassium oxonate could increase the level of uric acid,but could not maintain the high level of uric acid.The administration of 300 mg/kg potassium oxonate combined with 500 mg/kg uric acid solution could increase the level of uric acid in blood(the increase rate was 207.2%),but the high level of uric acid could not be maintained.The administration of 300 mg/kg potassium oxonate combined with 500 mg/kg hypoxanthine solution could increase the serum uric acid level(the increase rate was 384.4%),but the high level of uric acid could not be maintained either.The administration of 300 mg/kg potassium oxonate combined with 250 mg/kg ethambutol solution could increase the serum uric acid level(the increase rate was 320.8%),and the high level of uric acid could be maintained stably.Conclusion The combination of potassium oxazinate and ethambutol could successfully increase the uric acid value of ICR mice and stably maintain the level of uric acid.The modeling effect was better than that of single potassium oxonate,potassium oxonate combined with uric acid and oxygen,potassium oxonate combined with hypoxanthine.

Key words： Hyperuricemia Uric acid Hypoxanthine Potassium oxonate Ethambutol

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	Articles by authors
	HAN Quan
	WANG Yu-zhi
	FU Guo-feng
	GUO Lu
	HU Liu
	WU Yan
	SHEN Yan

Cite this article:

HAN Quan,WANG Yu-zhi,FU Guo-feng, et al. Effect of potassium oxonate combined with different modelling agents on the uric acid value of hyperuricemia in mice[J]. 中国当代医药, 2021, 28(18): 21-25.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I18/21

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