血清非高密度脂蛋白胆固醇与脑梗死急性期神经功能损害的相关性分析

Abstract
Figure/Table
References (20)
Related Citation (15)

Download: PDF (0 KB) HTML (36 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the correlation between serum non-high density lipoprotein-cholesterol(non-HDL-C)and neurological impairment in acute phase of cerebral infarction.Methods A total of 132 patients with cerebral infarction admitted to the Department of Neurology,Zhaoqing Hospital of Traditional Chinese Medicine from April 2018 to May 2020 were selected as the research objects,and 66 healthy people during the same period were selected as the control group.The differences of blood lipid levels between the two groups were analyzed.According to the level of non-HDL-C,the patients with cerebral infarction were divided into normal non-HDL-C group and elevated non-HDL-C group.The clinical data,blood lipid levels and neurological function scores of patients with different levels of non-HDL-C were compared.The correlation between non-LDL-C level and other blood lipid indexes,neurological function indexes was analyzed.Results The level of HDL-C in the cerebral infarction group was lower than that in the control group,and the levels of non-HDL-C,low-density lipoprotein cholesterol(LDL-C),total cholesterol(TC),and triacylglycerol(TG)were higher than those in the control group,the differences were statistically significant(P<0.05).The proportion of male in patients with elevated non-HDL-C was higher than that in patients with normal non-HDL-C,the difference was statistically significant(P<0.05).The levels TC,non-HDL-C,LDL-C,TG and National Institutes of Health stroke scale(NIHSS)score in patients with elevated non-HDL-C were higher than those in patients with normal non-HDL-C,while HDL-C level and Scandinavian stroke scale(SSS)score were lower than those in patients with normal non-HDL-C,with statistically significant differences(P<0.05).The non-HDL-C was positively correlated with TC,LDL-C,TG and NIHSS score,but negatively correlated with HDL-C and SSS score(P<0.05).Conclusion Serum non-HDL-C has a significant positive correlation with neurological impairment in acute stage of cerebral infarction,which can be used as a marker for evaluating neurological impairment in cerebral infarction.

Key words： Non-high density lipoprotein-cholesterol Acute phase of cerebral infarction Neurological function Triglycerides

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	WANG Ming-nan
	WAN Ze-min
	LOU Qing
	OU Yong-guang

Cite this article:

WANG Ming-nan,WAN Ze-min,LOU Qing, et al. Correlation analysis between serum non-high density lipoprotein-cholesterol and neurological impairment in acute phase of cerebral infarction[J]. 中国当代医药, 2021, 28(18): 4-7.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I18/4

[1]	王素匣，吴虹辰，文岚，等.急性脑梗死取栓患者血栓成分与预后的特性分析[J].第三军医大学学报，2019，41（20）：1976-1981.
[2]	康建华，杨立顺，袁海生.脂蛋白相关磷脂酶A2 与急性脑梗死危险因素的相关性[J].中国老年学杂志，2017，37（2）：333-336.
[3]	王建丽，吴明华.非高密度与残粒脂蛋白胆固醇对青年家族聚集性急性脑卒中预后的预测评价[J].中国实用神经疾病杂志，2020，23（12）：1086-1090.
[4]	中国心血管病预防指南（2017）写作组，中华心血管病杂志编辑委员会.中国心血管病预防指南（2017）[J].中华心血管病杂志，2018，46（1）：10-25.
[5]	蔡必扬，郭洪权，李华.关于美国国立卫生研究院卒中量表翻译的警示[J].中华神经科杂志，2017，50（9）：712.
[6]	周璇，薛艺东，郭杰.奥拉西坦配合常规疗法治疗急性脑梗死患者的疗效及对认知功能的影响[J].脑与神经疾病杂志，2019，27（2）：103-106.
[7]	中国心血管病风险评估和管理指南编写联合委员会.中国心血管病风险评估和管理指南[J].中国循环杂志，2019，34（1）：4-28.
[8]	Ni T，Fu Y，Zhou W，et al.Carotid plaques and neurological impairment in patients with acute cerebral infarction[J].PLoS One，2020，15（1）：e0226961.
[9]	Bao GQ，Yu JY.Vitamin D3 promotes cerebral angiogenesis after cerebral infarction in rats by activating Shh signaling pathway[J].Eur Rev Med Pharmacol Sci，2018，22（20）：7069-7077.
[10]	王莎，贺龙，王东红，等.非高密度脂蛋白胆固醇与血管性认知障碍的相关性[J].中国老年学杂志，2019，39（12）：2866-2870.
[11]	刘秦，方勇涛，李少明.非高密度脂蛋白胆固醇水平对动脉硬化性脑梗死患者预后的影响[J].卒中与神经疾病，2017，24（4）：342-344.
[12]	刘于庭，马欢，尹晗，等.冠心病介入治疗患者非高密度脂蛋白胆固醇达标情况与预后的关系研究[J].中国全科医学，2020，23（19）：2435-2440，2445.
[13]	黄家中，郑黎强，孙英贤，等.阜新农村地区高血压人群非高密度脂蛋白胆固醇水平与脑卒中发病的关系[J].中国动脉硬化杂志，2016，24（12）：1265-1268.
[14]	谢晨，马爱娟，姜博，等.北京市职业人群非高密度脂蛋白胆固醇水平及其危险因素分析[J].中国慢性病预防与控制，2018，26（10）：730-734.
[15]	蔡俊秀，樊露，张伟晴，等.急性后循环脑梗死患者早期神经功能恶化的影响因素分析[J].中华老年心脑血管病杂志，2019，21（8）：852-855.
[16]	郭言伟，张敏，梅雨晴，等.急性缺血性脑卒中患者中国缺血性卒中亚型分型与早期神经功能恶化的关系[J].中华老年心脑血管病杂志，2020，22（1）：44-46.
[17]	华键，周其达.急性脑梗死早期神经功能恶化与高密度脂蛋白胆固醇及脂蛋白（a）的关系[J].中华老年心脑血管病杂志，2018，20（4）：405-407.
[18]	陆达，郑娜，李攀，等.血清非高密度脂蛋白胆固醇对缺血性脑卒中患者急性期神经功能损害的影响[J].中国动脉硬化杂志，2017，25（9）：923-927.
[19]	刘秋皖，吴竹青，王小强，等.大动脉粥样硬化型脑卒中患者应用大剂量瑞舒伐他汀的临床观察[J].中华老年心脑血管病杂志，2018，20（3）：278-281.
[20]	郭鑫，王静，路月英，等.脑卒中后抑郁与血清胆红素及非高密度脂蛋白胆固醇的关系[J].中国老年学杂志，2019，39（1）：101-104.